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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5458
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pubmed:dateCreated |
2000-3-23
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pubmed:databankReference |
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pubmed:abstractText |
The synergistic response of cells to the stimulation of multiple receptors has been ascribed to receptor cross talk; however, the specific molecules that mediate the resultant signal amplification have not been defined. Here a 24-kilodalton single transmembrane protein, designated calcyon, we functionally characterize that interacts with the D1 dopamine receptor. Calcyon localizes to dendritic spines of D1 receptor-expressing pyramidal cells in prefrontal cortex. These studies delineate a mechanism of Gq- and Gs-coupled heterotrimeric GTP-binding protein-coupled receptor cross talk by which D1 receptors can shift effector coupling to stimulate robust intracellular calcium (Ca2+i) release as a result of interaction with calcyon. The role of calcyon in potentiating Ca2+-dependent signaling should provide insight into the D1 receptor-modulated cognitive functions of prefrontal cortex.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzazepines,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Heterotrimeric GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurotransmitter,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SK&F 81297
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
287
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1660-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10698743-Amino Acid Sequence,
pubmed-meshheading:10698743-Animals,
pubmed-meshheading:10698743-Benzazepines,
pubmed-meshheading:10698743-Brain,
pubmed-meshheading:10698743-Calcium,
pubmed-meshheading:10698743-Calcium Signaling,
pubmed-meshheading:10698743-Cell Line,
pubmed-meshheading:10698743-Cyclic AMP,
pubmed-meshheading:10698743-Dendrites,
pubmed-meshheading:10698743-Dopamine Agonists,
pubmed-meshheading:10698743-Female,
pubmed-meshheading:10698743-Heterotrimeric GTP-Binding Proteins,
pubmed-meshheading:10698743-Humans,
pubmed-meshheading:10698743-Macaca mulatta,
pubmed-meshheading:10698743-Membrane Proteins,
pubmed-meshheading:10698743-Molecular Sequence Data,
pubmed-meshheading:10698743-Prefrontal Cortex,
pubmed-meshheading:10698743-Pyramidal Cells,
pubmed-meshheading:10698743-Rabbits,
pubmed-meshheading:10698743-Receptor Cross-Talk,
pubmed-meshheading:10698743-Receptors, Dopamine D1,
pubmed-meshheading:10698743-Receptors, Neurotransmitter,
pubmed-meshheading:10698743-Recombinant Fusion Proteins,
pubmed-meshheading:10698743-Signal Transduction,
pubmed-meshheading:10698743-Two-Hybrid System Techniques
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pubmed:year |
2000
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pubmed:articleTitle |
Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein.
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pubmed:affiliation |
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912-2300, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Retracted Publication
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