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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1977-2-16
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pubmed:abstractText |
To establish that alkaline phosphatase (AP) was released by osteosarcoma cells, we measured this enzyme in C3H/HeJ mice with im-implanted osteosarcoma and in in vitro cultures of neoplastic cells subjected to short-term incubation. We found that 10(5) osteosarcoma cells synthesized a significant amount of AP in vitro in 30 minutes at 37 degrees C. A good correlation existed between pulmonary metastatic tumors and the AP values. Serum AP measurements indicated approximate sizes of disseminated and localized tumors, but could not monitor early localized tumors.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0027-8874
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
57
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
837-9
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1069857-Alkaline Phosphatase,
pubmed-meshheading:1069857-Animals,
pubmed-meshheading:1069857-Female,
pubmed-meshheading:1069857-Lung Neoplasms,
pubmed-meshheading:1069857-Mice,
pubmed-meshheading:1069857-Mice, Inbred C3H,
pubmed-meshheading:1069857-Neoplasm Metastasis,
pubmed-meshheading:1069857-Organ Size,
pubmed-meshheading:1069857-Osteosarcoma,
pubmed-meshheading:1069857-Sarcoma, Experimental,
pubmed-meshheading:1069857-Time Factors
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pubmed:year |
1976
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pubmed:articleTitle |
Monitoring of murine osteosarcoma by serial alkaline phosphatase determinations.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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