Linked Life Data

10697593

Source:http://linkedlifedata.com/resource/pubmed/id/10697593

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6A
pubmed:dateCreated
2000-3-16
pubmed:abstractText
It is widely recognized that growth factors play critical roles in cell proliferation and differentiation. In the early 1980s, several members of the transforming growth factor-beta (TGF-beta) superfamily were identified and subsequently shown to play important roles in many diseases, in particular cancer. Efforts to understand how TGF-beta exerts its effects led to identification of TGF-beta-receptors and several downstream signaling pathways activated by this family of growth factors. This review provides an overview of TGF-beta-receptors and its downstream signaling pathways. As part of this discussion, this review indicates that inactivation of TGF-beta-receptors or components of their signaling pathways is often a target during carcinogenesis and that mutations or altered expression at any step along this complex, growth regulatory pathway can lead to aberrant cell proliferation. Lastly, the Cancer Genome Anatomy Project is briefly discussed, in particular how it may help to identify aberrant growth factor expression during carcinogenesis and improve the diagnosis of cancer patients.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4791-807
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Growth regulatory factors and carcinogenesis: the roles played by transforming growth factor beta, its receptors and signaling pathways.
pubmed:affiliation
Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha 68198-6805, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review