Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-3-21
pubmed:abstractText
Protein inhibitor of neuronal nitric oxide synthase (PIN) is reported as the protein inhibiting neuronal nitric oxide synthase (nNOS) activity by preventing dimerization of nNOS. It was also reported that PIN inhibits the activity of all nitric oxide synthase (NOS) isozymes. We examined the effects of facial nerve transection on PIN mRNA and NOS expression by in situ hybridization for PIN mRNA and nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) staining. PIN mRNA was initially expressed and transiently increased from 3 to 5 days and returned to the basal level at 7 days after axotomy in the motoneurons of the facial nucleus. NADPH-d-positive motoneurons were found from 7 days post-operation in the facial nucleus. These results suggest that PIN may interact with NOS from 7 days post-operation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0891-0618
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
199-206
pubmed:dateRevised
2009-12-11
pubmed:meshHeading
pubmed-meshheading:10697246-Animals, pubmed-meshheading:10697246-Axotomy, pubmed-meshheading:10697246-Brain, pubmed-meshheading:10697246-Brain Stem, pubmed-meshheading:10697246-Carrier Proteins, pubmed-meshheading:10697246-Dihydrolipoamide Dehydrogenase, pubmed-meshheading:10697246-Drosophila Proteins, pubmed-meshheading:10697246-Dyneins, pubmed-meshheading:10697246-Enzyme Inhibitors, pubmed-meshheading:10697246-Facial Nerve, pubmed-meshheading:10697246-Gene Expression Regulation, pubmed-meshheading:10697246-Male, pubmed-meshheading:10697246-Nitric Oxide Synthase, pubmed-meshheading:10697246-Nitric Oxide Synthase Type I, pubmed-meshheading:10697246-RNA, Messenger, pubmed-meshheading:10697246-Rats, pubmed-meshheading:10697246-Rats, Sprague-Dawley, pubmed-meshheading:10697246-Reference Values, pubmed-meshheading:10697246-Transcription, Genetic
pubmed:year
2000
pubmed:articleTitle
Changes in mRNA of protein inhibitor of neuronal nitric oxide synthase following facial nerve transection.
pubmed:affiliation
Department of Anatomy and Neuroscience, Osaka University Medical School, Japan. che@anat2.med.osaka-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't