Linked Life Data

10695761

Source:http://linkedlifedata.com/resource/pubmed/id/10695761

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-3-21
pubmed:abstractText
We model experience-dependent plasticity in the adult rat S1 cortical representation of the whiskers (the barrel cortex) which has been produced by trimming all whiskers on one side of the snout except two. This manipulation alters the pattern of afferent sensory activity while avoiding any direct nerve damage. Our simplified model circuitry represents multiple cortical layers and inhibitory neurons within each layer of a barrel-column. Utilizing a computational model we show that the evolution of the response bias in the barrel-column towards spared whiskers is consistent with synaptic modifications that follow the rules of the Bienenstock, Cooper and Munro (BCM) theory. The BCM theory postulates that a neuron possesses a dynamic synaptic modification threshold, thetaM, which dictates whether the neuron's activity at any given instant will lead to strengthening or weakening of the synapses impinging on it. However, the major prediction of our model is the explanation of the delay in response potentiation in the layer-IV neurons through a masking effect produced by the thresholded monotonically increasing inhibition expressed by either the logarithmic function, h(x) = mu log(1 + x), or by the power function, h(x) = mu x(0.8-0.9), where mu is a constant. Furthermore, simulated removal of the supragranular layers (layers II/III) reduces plasticity of neurons in the remaining layers (IV-VI) and points to the role of noise in synaptic plasticity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0954-898X
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
303-23
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Computational study of experience-dependent plasticity in adult rat cortical barrel-column.
pubmed:affiliation
Department of Computer Science and Engineering, Slovak Technical University, Bratislava. benus@elf.stuba.sk
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't