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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-4-24
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pubmed:abstractText |
1. The effects of L-cysteine were tested in rat aortic rings on responses to nitric oxide free radical (NO(*)), nitroxyl (NO(-)) derived from Angeli's salt and endothelium-derived relaxing factor (EDRF) activated by acetylcholine, ATP and the calcium ionophore A23187. Concentrations of 300 microM or less of L-cysteine had no effect on responses. 2. Relaxations produced by exogenous NO(*) (0.25 - 2.5 microM) were markedly prolonged and relaxations produced by sodium nitroprusside (0.001 - 0.3 microM) were enhanced by 1 and 3 mM L-cysteine. The enhancements by L-cysteine of responses to NO(*) and sodium nitroprusside may be attributed to the formation of S-nitrosocysteine. 3. Relaxations mediated by the nitroxyl anion (0.3 microM) donated from Angeli's salt were more prolonged than those produced by NO(*), and nitroxyl-induced relaxations were reduced by L-cysteine (1 and 3 mM). 4. EDRF-mediated relaxations produced by acetylcholine (0.01 - 10 microM), ATP (3 - 100 microM) and the calcium ionophore A23187 (0.1 microM) were significantly reduced by 3 mM L-cysteine. 5. The similarity between the inhibitory effects of L-cystei on responses to EDRF and on those to nitroxyl suggests that a component of the response to EDRF may be mediated by nitroxyl anion.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-10051139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-10193785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-10433488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-1325360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-1331403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-1540216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-1628152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-2175799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-3121364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-3886674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-6253831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-6293586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-6876518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-7505326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-7582532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-7828648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-7870284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-7923362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-8032616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-8107883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-8229764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-8422387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-8428210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-8428610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-8526840,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-9454793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-9488098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-9497319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-9548918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-9919569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10694238-9919577
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Calcimycin,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radicals,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Donors,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrogen Oxides,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroprusside,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents,
http://linkedlifedata.com/resource/pubmed/chemical/nitroxyl
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
129
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
315-22
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10694238-Acetylcholine,
pubmed-meshheading:10694238-Adenosine Triphosphate,
pubmed-meshheading:10694238-Animals,
pubmed-meshheading:10694238-Aorta, Thoracic,
pubmed-meshheading:10694238-Calcimycin,
pubmed-meshheading:10694238-Cysteine,
pubmed-meshheading:10694238-Endothelium, Vascular,
pubmed-meshheading:10694238-Free Radicals,
pubmed-meshheading:10694238-Male,
pubmed-meshheading:10694238-Muscle, Smooth, Vascular,
pubmed-meshheading:10694238-Muscle Relaxation,
pubmed-meshheading:10694238-Nitric Oxide,
pubmed-meshheading:10694238-Nitric Oxide Donors,
pubmed-meshheading:10694238-Nitrogen Oxides,
pubmed-meshheading:10694238-Nitroprusside,
pubmed-meshheading:10694238-Phenylephrine,
pubmed-meshheading:10694238-Rats,
pubmed-meshheading:10694238-Rats, Sprague-Dawley,
pubmed-meshheading:10694238-Vasoconstrictor Agents
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pubmed:year |
2000
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pubmed:articleTitle |
Differential actions of L-cysteine on responses to nitric oxide, nitroxyl anions and EDRF in the rat aorta.
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pubmed:affiliation |
Pharmacology Research Unit, Department of Medical Laboratory Science, RMIT University, GPO Box 2476V, Melbourne, Victoria, 3001, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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