|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2000-3-30
|
|
pubmed:abstractText |
The T-type prevalent calcium channel blocker mibefradil (MIB) was shown to possess N-type calcium channel blocking properties. As this particular type of calcium channel is known to be crucially involved in the neuronal release of noradrenaline, we have investigated whether MIB could be a sympatholytic drug.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0263-6352
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
203-7
|
|
pubmed:dateRevised |
2003-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:10694189-Animals,
pubmed-meshheading:10694189-Calcium Channel Blockers,
pubmed-meshheading:10694189-Calcium Channels, L-Type,
pubmed-meshheading:10694189-Decerebrate State,
pubmed-meshheading:10694189-Electric Stimulation,
pubmed-meshheading:10694189-Heart Rate,
pubmed-meshheading:10694189-Male,
pubmed-meshheading:10694189-Mibefradil,
pubmed-meshheading:10694189-Norepinephrine,
pubmed-meshheading:10694189-Rats,
pubmed-meshheading:10694189-Rats, Wistar,
pubmed-meshheading:10694189-Sympathetic Nervous System,
pubmed-meshheading:10694189-Sympatholytics,
pubmed-meshheading:10694189-Verapamil
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Evidence for a sympatholytic effect of mibefradil in the pithed rat preparation.
|
|
pubmed:affiliation |
Department of Pharmacotherapy, Academic Medical Center, Amsterdam, The Netherlands. m.pfaffendorf@amc.uva.nl
|
|
pubmed:publicationType |
Journal Article
|
