Source:http://linkedlifedata.com/resource/pubmed/id/10693170
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2000-3-9
|
| pubmed:abstractText |
We examined the effects of garlic oil (GO) and two of its organosulfur compounds, diallyl sulfide (DAS) and diallyl disulfide (DADS), on the drug-metabolizing and antioxidant systems in rats and sought to determine whether these effects are associated with dietary fat. Rats were fed a high-fat diet and received GO or DADS (200 mg/kg body wt) or DAS (100 mg/kg) orally three times a week for seven weeks. Control animals received corn oil alone. Another group of rats was fed a low-fat diet, with or without GO. GO and DADS significantly reduced the body weight gain of rats (p < 0.05). GO, however, dramatically increased the spleen weight and spleen weight-to-body weight ratio (p < 0.05). DAS increased glutathione S-transferase (GST) and 7-pentoxyresorufin O-dealkylase activities, whereas DADS increased only GST activity (p < 0.05). Immunoblot assay showed GO-, DAS-, and DADS-enhanced expression of the placental form of GST and cytochrome P-450 IIBI but suppressed cytochrome P-450 IIEI expression. Hepatic antioxidant enzyme activities were also modulated by these garlic components. GO and DADS inhibited glutathione peroxidase activity (p < 0.05), and DADS and DAS enhanced glutathione reductase activity (p < 0.05). Only GO enhanced the superoxide dismutase activity (p < 0.05). All these garlic components increased glutathione levels in red blood cells (p < 0.05) but did not influence hepatic glutathione levels. Although the amount of fat in the diet modulated drug-metabolizing and antioxidant functions, no interactions between GO and dietary fat were observed. These results indicate that GO and its allyl sulfide components, as well as dietary lipid, modulate drug-metabolizing and antioxidant enzyme activities. The action of GO appears to be independent of dietary lipid content.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Allyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2B1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2E1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Reductase,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH-Ferrihemoprotein Reductase,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfides,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfur Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/allyl sulfide
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0163-5581
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
160-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10693170-Allyl Compounds,
pubmed-meshheading:10693170-Animals,
pubmed-meshheading:10693170-Antioxidants,
pubmed-meshheading:10693170-Cytochrome P-450 CYP2B1,
pubmed-meshheading:10693170-Cytochrome P-450 CYP2E1,
pubmed-meshheading:10693170-Cytochrome P-450 Enzyme System,
pubmed-meshheading:10693170-Diet, Fat-Restricted,
pubmed-meshheading:10693170-Dietary Fats,
pubmed-meshheading:10693170-Erythrocytes,
pubmed-meshheading:10693170-Glutathione Reductase,
pubmed-meshheading:10693170-Glutathione Transferase,
pubmed-meshheading:10693170-Liver,
pubmed-meshheading:10693170-Male,
pubmed-meshheading:10693170-NADPH-Ferrihemoprotein Reductase,
pubmed-meshheading:10693170-Rats,
pubmed-meshheading:10693170-Rats, Sprague-Dawley,
pubmed-meshheading:10693170-Sulfides,
pubmed-meshheading:10693170-Sulfur Compounds,
pubmed-meshheading:10693170-Superoxide Dismutase
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Effects of garlic oil and its organosulfur compounds on the activities of hepatic drug-metabolizing and antioxidant enzymes in rats fed high- and low-fat diets.
|
| pubmed:affiliation |
Department of Nutrition, China Medical College, Taichung, Taiwan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|