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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2000-3-13
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pubmed:abstractText |
Early pregnancy is maintained in ruminants through the actions of conceptus-derived interferon (IFN)-tau on the endometrium. IFN-tau alters uterine release of PGF2 alpha' which results in rescue of the corpus luteum and continued release of progesterone. The mechanism of action of IFN-tau includes inhibition of oestradiol receptors, consequent reduction in oxytocin receptors, activation of a cyclooxygenase inhibitor, and a shift in the PGs to favour PGE2 over PGF2 alpha' IFN-tau also induces several endometrial proteins that may be critical for survival of the developing embryo. One endometrial protein induced by pregnancy and IFN-tau has been identified as bovine granulocyte chemotactic protein-2 (bGCP-2). This chemotactic cytokine (chemokine) has been used as a marker to delineate IFN-tau from IFN-alpha responses in the endometrium. A second protein, called ubiquitin cross-reactive protein (UCRP), resembles a tandem ubiquitin repeat. UCRP becomes conjugated to cytosolic endometrial proteins in response to IFN-tau and pregnancy. Proteins conjugated to UCRP are either modulated or targeted for processing through the proteasome. The action of IFN-tau is mediated by induction of signal transducer and activator of transcription 1 (STAT-1), STAT-2 and interferon regulatory factor 1 (IRF-1) transcription factors. Induction of these transcription factors, the alpha chemokines and UCRP is the prelude to maternal recognition of pregnancy in ruminants.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL6,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Cxcl2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprost,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Pregnancy Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interferon,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitins,
http://linkedlifedata.com/resource/pubmed/chemical/trophoblastin
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pubmed:status |
MEDLINE
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pubmed:issn |
0449-3087
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
329-39
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10692865-Amino Acid Sequence,
pubmed-meshheading:10692865-Animals,
pubmed-meshheading:10692865-Cattle,
pubmed-meshheading:10692865-Chemokine CXCL2,
pubmed-meshheading:10692865-Chemokine CXCL6,
pubmed-meshheading:10692865-Chemokines,
pubmed-meshheading:10692865-Chemokines, CXC,
pubmed-meshheading:10692865-Corpus Luteum Maintenance,
pubmed-meshheading:10692865-Dinoprost,
pubmed-meshheading:10692865-Dinoprostone,
pubmed-meshheading:10692865-Embryo, Mammalian,
pubmed-meshheading:10692865-Female,
pubmed-meshheading:10692865-Interferon Type I,
pubmed-meshheading:10692865-Molecular Sequence Data,
pubmed-meshheading:10692865-Pregnancy,
pubmed-meshheading:10692865-Pregnancy, Animal,
pubmed-meshheading:10692865-Pregnancy Proteins,
pubmed-meshheading:10692865-Progesterone,
pubmed-meshheading:10692865-Protein Binding,
pubmed-meshheading:10692865-Receptors, Estradiol,
pubmed-meshheading:10692865-Receptors, Interferon,
pubmed-meshheading:10692865-Ubiquitins
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pubmed:year |
1999
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pubmed:articleTitle |
Mechanism of action of interferon-tau in the uterus during early pregnancy.
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pubmed:affiliation |
Department of Animal Science, University of Wyoming, Laramie 82071, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Review,
Research Support, Non-U.S. Gov't
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