Source:http://linkedlifedata.com/resource/pubmed/id/10692600
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
|
pubmed:dateCreated |
2000-4-11
|
pubmed:abstractText |
The aim of this study was to investigate the effect of injection of serotonin (5-HT) into the masseter muscle on pain and allodynia/hyperalgesia. Twelve female patients with fibromyalgia (FM) and 12 age-matched female healthy individuals (HI) participated in the study. The current pain intensity (CPI) and the pressure pain threshold (PPT) of the superficial masseter muscles were assessed bilaterally. 5-HT in one of three randomized concentrations (10(-3), 10(-5), 10(-7) M) or isotonic saline was then injected into either of the two masseter muscles in a double-blind manner. After the injections the CPI and PPT were recorded ten times during 30 min. The injections were repeated twice with the other concentrations of 5-HT after 1 and 2 weeks, respectively. In the FM-group there was a non-significant increase of CPI after injection that lasted during the entire 30-min period irrespective of whether 5-HT or saline was injected. Neither did the PPT change significantly. In the HI-group pain developed significantly after injection irrespective of whether 5-HT or saline was injected, but significantly more so after 5-HT at 10(-3) M than saline injection. CPI decreased quickly and then remained on a very low level for most of the experiment. 5-HT at both 10(-5) M and 10(-3) M caused a significantly greater decrease of PPT than saline. In conclusion, our results show that 5-HT injected into the masseter muscle of healthy female subjects elicits pain and allodynia/hyperalgesia, while no such responses occur in patients with fibromyalgia.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0304-3959
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
85
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
31-9
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:10692600-Adult,
pubmed-meshheading:10692600-Double-Blind Method,
pubmed-meshheading:10692600-Female,
pubmed-meshheading:10692600-Fibromyalgia,
pubmed-meshheading:10692600-Humans,
pubmed-meshheading:10692600-Hyperalgesia,
pubmed-meshheading:10692600-Injections, Intramuscular,
pubmed-meshheading:10692600-Masseter Muscle,
pubmed-meshheading:10692600-Middle Aged,
pubmed-meshheading:10692600-Pain,
pubmed-meshheading:10692600-Pain Measurement,
pubmed-meshheading:10692600-Pain Threshold,
pubmed-meshheading:10692600-Pressure,
pubmed-meshheading:10692600-Serotonin
|
pubmed:year |
2000
|
pubmed:articleTitle |
Pain and allodynia/hyperalgesia induced by intramuscular injection of serotonin in patients with fibromyalgia and healthy individuals.
|
pubmed:affiliation |
Department of Clinical Oral Physiology, Institute of Odontology, Box 4064, S-141 04, Huddinge, Sweden. malin.ernberg@ofa.ki.se
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|