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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-4-13
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pubmed:abstractText |
The accumulation of endogenous bile acids contributes to hepatocellular damage during cholestatic liver disease. To evaluate the potential role of apoptotic cell death due to increased concentrations of bile acids, primary human hepatocytes were treated with hydrophobic and hydrophilic bile acids. Because the Fas receptor-ligand system may mediate apoptosis in human liver cells, the effect of toxic bile acids on hepatocellular Fas receptor expression was evaluated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-2972
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
203-9
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10691996-Antigens, CD95,
pubmed-meshheading:10691996-Apoptosis,
pubmed-meshheading:10691996-Aspartate Aminotransferases,
pubmed-meshheading:10691996-Bile Acids and Salts,
pubmed-meshheading:10691996-Cells, Cultured,
pubmed-meshheading:10691996-DNA Fragmentation,
pubmed-meshheading:10691996-Humans,
pubmed-meshheading:10691996-In Situ Nick-End Labeling,
pubmed-meshheading:10691996-Liver,
pubmed-meshheading:10691996-Taurochenodeoxycholic Acid
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pubmed:year |
2000
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pubmed:articleTitle |
Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes.
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pubmed:affiliation |
Department of Medicine; Department of Anatomy and Cell Biology, University of Heidelberg, Germany.
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pubmed:publicationType |
Journal Article
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