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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-3-14
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pubmed:abstractText |
Vincristine is an active agent in lymphomas, but is often neurotoxic, and the resulting dose reductions have been associated with lower remission and survival rates in Hodgkin's disease. Liposomal vincristine (Onco-TCS) has prolonged half-life, reaches higher concentration in tumors and lymph nodes than in nerves, and administered at full doses appears to be less neurotoxic, and more active then free vincristine in mice bearing L-1210 and P-388 leukemias. We therefore explored its activity in relapsed non-Hodgkin's lymphomas (NHL) and acute lymphoblastic leukemia (ALL).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0923-7534
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pubmed:author |
pubmed-author:BurgeCC,
pubmed-author:CabanillasFF,
pubmed-author:HagemeisterFF,
pubmed-author:KantarjianHH,
pubmed-author:McLaughlinPP,
pubmed-author:MedeirosL JLJ,
pubmed-author:NeilM JMJ,
pubmed-author:OholendtMM,
pubmed-author:RodriguezM AMA,
pubmed-author:RomagueraJJ,
pubmed-author:SamuelsBB,
pubmed-author:SarrisA HAH,
pubmed-author:TsimberidouA MAM
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69-72
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10690390-Adult,
pubmed-meshheading:10690390-Aged,
pubmed-meshheading:10690390-Aged, 80 and over,
pubmed-meshheading:10690390-Animals,
pubmed-meshheading:10690390-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:10690390-Disease-Free Survival,
pubmed-meshheading:10690390-Drug Carriers,
pubmed-meshheading:10690390-Female,
pubmed-meshheading:10690390-Humans,
pubmed-meshheading:10690390-Liposomes,
pubmed-meshheading:10690390-Lymphoma, Non-Hodgkin,
pubmed-meshheading:10690390-Male,
pubmed-meshheading:10690390-Mice,
pubmed-meshheading:10690390-Middle Aged,
pubmed-meshheading:10690390-Neoplasm Staging,
pubmed-meshheading:10690390-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:10690390-Recurrence,
pubmed-meshheading:10690390-Survival Analysis,
pubmed-meshheading:10690390-Vincristine
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pubmed:year |
2000
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pubmed:articleTitle |
Liposomal vincristine in relapsed non-Hodgkin's lymphomas: early results of an ongoing phase II trial.
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pubmed:affiliation |
Department of Lymphoma and Myeloma, University of Texas M.D. Anderson Cancer Center, Houston, USA. asarris@notes.mdacc.tmc.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Clinical Trial, Phase II
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