|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2000-3-13
|
|
pubmed:abstractText |
We examined the effect of the suppression of plasma angiotensinogen (AGT) by the intravenous injection of antisense oligodeoxynucleotides (ODNs) against AGT targeted to the liver on cardiac remodeling in spontaneously hypertensive rats (SHR). The ODNs against rat AGT were coupled to asialoglycoprotein (ASOR) carrier molecules, which serve as an important method for regulating liver gene expression.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensinogen,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Angiotensin
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0008-6363
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
44
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
543-8
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:10690286-Analysis of Variance,
pubmed-meshheading:10690286-Angiotensin II,
pubmed-meshheading:10690286-Angiotensinogen,
pubmed-meshheading:10690286-Animals,
pubmed-meshheading:10690286-Cardiomegaly,
pubmed-meshheading:10690286-Gene Expression,
pubmed-meshheading:10690286-Gene Therapy,
pubmed-meshheading:10690286-Injections, Intravenous,
pubmed-meshheading:10690286-Liver,
pubmed-meshheading:10690286-Male,
pubmed-meshheading:10690286-Myocardium,
pubmed-meshheading:10690286-Oligodeoxyribonucleotides, Antisense,
pubmed-meshheading:10690286-RNA, Messenger,
pubmed-meshheading:10690286-Rats,
pubmed-meshheading:10690286-Rats, Inbred SHR,
pubmed-meshheading:10690286-Rats, Inbred WKY,
pubmed-meshheading:10690286-Receptor, Angiotensin, Type 1,
pubmed-meshheading:10690286-Receptor, Angiotensin, Type 2,
pubmed-meshheading:10690286-Receptors, Angiotensin,
pubmed-meshheading:10690286-Ventricular Remodeling
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Chronic antisense therapy for angiotensinogen on cardiac hypertrophy in spontaneously hypertensive rats.
|
|
pubmed:affiliation |
Department of Bioclimatology, Kyushu University, Beppu, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
