Linked Life Data

10689123

Source:http://linkedlifedata.com/resource/pubmed/id/10689123

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-3-27
pubmed:abstractText
Trypanosomiasis is an important cause of cardiomyopathy in endemic rural areas of Latin America. Previous studies have suggested participation of HLA molecules in the immune response regulation of T. cruzi infection, and association of HLA antigens with heart damage. One hundred and eleven unrelated T. cruzi antigen-seropositive individuals were tested for HLA class II alleles by the polymerase chain reaction and sequence specific oligonucleotide (PCR-SSO) method. Patients were classified in 3 groups according to clinical and electrocardiographic characteristics: asymptomatics (group A), with arrhythmia (group B), and with overt congestive heart failure (group C). Statistical analysis confirmed the significant increment of the DRB1*01 DQB1*0501 haplotype (p = 0.03) previously reported by our laboratory in patients with cardiomyopathy. The DPB1*0401 allele frequency is also significantly increased in patients with heart disease (groups B + C) (p = 0.009) while DPB1*0101 frequency is higher among the asymptomatic group (p = 0.04) compared with individuals of group C. The DPB1*0401 allele in homozygous form or in combination with allele DPB1*2301 or 3901, was found present more often in patients of groups B and C. Thus, the combination of two of these three alleles, sharing specific sequence motifs in positions 8, 9, 76, and 84-87 confers a relative risk of 6.55 to develop cardiomyopathy in seropositive patients (p = 0.041). Furthermore, 32% of the cardiomyopathics have either DRB1*01 DQB1*0501 and/or DPB1*0401/*0401, 0401/*2301, or* 0401/*3901 compared with 9% of the seropositive asymptomatics (OR = 5.0; p = 0.006).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0198-8859
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
320-5
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:10689123-Amino Acid Sequence, pubmed-meshheading:10689123-Animals, pubmed-meshheading:10689123-Chagas Cardiomyopathy, pubmed-meshheading:10689123-Gene Frequency, pubmed-meshheading:10689123-Genes, MHC Class II, pubmed-meshheading:10689123-Genetic Predisposition to Disease, pubmed-meshheading:10689123-HLA-DP Antigens, pubmed-meshheading:10689123-HLA-DP beta-Chains, pubmed-meshheading:10689123-HLA-DQ Antigens, pubmed-meshheading:10689123-HLA-DQ beta-Chains, pubmed-meshheading:10689123-HLA-DR Antigens, pubmed-meshheading:10689123-HLA-DRB1 Chains, pubmed-meshheading:10689123-Haplotypes, pubmed-meshheading:10689123-Humans, pubmed-meshheading:10689123-Molecular Sequence Data, pubmed-meshheading:10689123-Polymorphism, Genetic, pubmed-meshheading:10689123-Sequence Homology, Amino Acid, pubmed-meshheading:10689123-Venezuela
pubmed:year
2000
pubmed:articleTitle
HLA class II DRB1, DQB1, DPB1 polymorphism and cardiomyopathy due to Trypanosoma cruzi chronic infection.
pubmed:affiliation
Instituto Venezolano de Investigaciones Cientificas (IVIC), Laboratorio de Fisiopatologia, Caracas and Centro de Investigaciones Jose Francisco Torrealba, San Juan de Los Morros, Venezuela.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't