Source:http://linkedlifedata.com/resource/pubmed/id/10689037
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2000-4-25
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| pubmed:abstractText |
Three groups of patients with Parkinson's disease (PD) - mild, unmedicated (UPD), mild, medicated (MPD) and severe, medicated (SPD) - and patients with lesions of the frontal lobe (FLL) or temporal lobe (TLL) were compared with matched controls on the learning and reversal of probabilistic and two-pair concurrent colour discriminations. Both of the cortical lesion groups showed reversal deficits, with no increase in perseverative responding. The UPD group, although impaired on a spatial recognition task, showed intact discrimination learning and reversal; the MPD and SPD patients showed non-perseverative reversal impairments on both reversal tasks. Two hypotheses - based on disease severity and possible deleterious effects of medication - are offered to explain the reversal impairments of the PD patients and the results are discussed in terms of the role of dopamine in reward-based learning.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0028-3932
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
38
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
596-612
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| pubmed:dateRevised |
2009-11-11
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| pubmed:meshHeading |
pubmed-meshheading:10689037-Adult,
pubmed-meshheading:10689037-Antiparkinson Agents,
pubmed-meshheading:10689037-Discrimination (Psychology),
pubmed-meshheading:10689037-Epilepsy,
pubmed-meshheading:10689037-Female,
pubmed-meshheading:10689037-Frontal Lobe,
pubmed-meshheading:10689037-Humans,
pubmed-meshheading:10689037-Learning Disorders,
pubmed-meshheading:10689037-Levodopa,
pubmed-meshheading:10689037-Male,
pubmed-meshheading:10689037-Models, Statistical,
pubmed-meshheading:10689037-Neostriatum,
pubmed-meshheading:10689037-Parkinson Disease,
pubmed-meshheading:10689037-Pattern Recognition, Visual,
pubmed-meshheading:10689037-Reversal Learning,
pubmed-meshheading:10689037-Space Perception,
pubmed-meshheading:10689037-Temporal Lobe,
pubmed-meshheading:10689037-Visual Perception
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication.
|
| pubmed:affiliation |
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK. rs211@cus.cam.ac.uk
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|