Linked Life Data

10684097

Source:http://linkedlifedata.com/resource/pubmed/id/10684097

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-4-25
pubmed:abstractText
This study was designed to evaluate the effect of estrogen on rat endometrium and compare the results of Nilestriol and Estradiol replacement therapies for preventing osteoporosis in ovariectomized rats. Forty 4-month old SD female rats were randomly divided into four groups, namely sham operation, bilateral ovariectomy, ovariectomy plus supplementary ethinyl estradiol (0.2 microgram/100 g B. W. qd x 5), and ovariectomy plus supplementary Nilestriol (0.15 mg/100 g B. W. once a week). Computerized image analyzer was used to evaluate the endomitrial pathological changes 10 weeks later. The results showed an atrophied endometrium in ovariectomized group, a slightly proliferative endometrium in Nilestriol treated group, and a markedly proliferative endometrium with local atypical hyperplasia in estradiol treated group. The difference between group 3 and group 4 in morphometry was significant (P < 0.5). These suggest the relative safety of Nilestriol replacement therapy for preventing menopausal osteoporosis.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0257-7712
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
295-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
[An endometrium morphometry study on ovariectomized rats subjected to nilestriol and estradiol replalcement therapies].
pubmed:affiliation
Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chengdu.
pubmed:publicationType
Journal Article, English Abstract