Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-3-2
pubmed:abstractText
The purpose of this work was to analyse the ability of p53 and thymidilate synthase (TS) primary tumour expression to retrospectively predict clinical response to chemotherapy and long-term prognosis in patients with advanced colorectal cancers homogeneously treated by methotrexate (MTX)-modulated-5-fluorouracil (5-FU-FA). A total of 108 advanced colorectal cancer patients entered the present retrospective study. Immunohistochemical p53 (pAb 1801 mAb) and TS (TS106 mAb) expression on formalin-fixed paraffin-embedded primary tumour specimens was related to probability of clinical response to chemotherapy, time to progression and overall survival. p53 was expressed in 53/108 (49%) tumours, while 54/108 (50%) showed TS immunostaining. No relationship was demonstrated between p53 positivity and clinical response to chemotherapy (objective response (OR): 20% vs 23%, in p53+ and p53- cases respectively) or overall survival. Percent of OR was significantly higher in TS-negative with respect to TS-positive tumours (30% vs 15% respectively; P < 0.04); simultaneous analysis of TS and p53 indicated 7% OR for p53-positive/TS-positive tumours vs 46% for p53-positive/TS-negative tumours (P < 0.03). Logistic regression analysis confirmed a significant association between TS tumour status and clinical response to chemotherapy (hazard ratio (HR): 2.91; 95% confidence interval (CI) 8.34-1.01; two-sided P < 0.05). A multivariate analysis of overall survival showed that only a small number of metastatic sites was statistically relevant (HR 1.89; 95% CI 2.85-1.26; two-sided P < 0.03). Our study suggests that immunohistochemical expression of p53 and TS could assist the clinician in predicting response of colorectal cancer patients to modulated MTX-5-FU therapy.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-1346476, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-1704999, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-1720706, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-1924359, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-2031508, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-2139577, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-4045529, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-6173112, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-7391086, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-7577040, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-7642470, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-7779704, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-7882343, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-7931471, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-7973635, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-7989939, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-8069852, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-8091232, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-8158699, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-8688317, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-8688324, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-8695163, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-8874329, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-8980242, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-8988119, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-9000137, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-9042268, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-9048835, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-9062414, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-9164203, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-9221816, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-9221853, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-9260894, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-9276707, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-9310257, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-9317168, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-9336359, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-9470819, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-9607583, http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-9816112
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-0920
pubmed:author
pubmed:issnType
Print
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
560-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Thymidilate synthase and p53 primary tumour expression as predictive factors for advanced colorectal cancer patients.
pubmed:affiliation
Clinical Experimental Oncology Laboratory, Oncology Institute, Bari, Italy. anpara@tin.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't