rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
2000-3-2
|
pubmed:abstractText |
The purpose of this work was to analyse the ability of p53 and thymidilate synthase (TS) primary tumour expression to retrospectively predict clinical response to chemotherapy and long-term prognosis in patients with advanced colorectal cancers homogeneously treated by methotrexate (MTX)-modulated-5-fluorouracil (5-FU-FA). A total of 108 advanced colorectal cancer patients entered the present retrospective study. Immunohistochemical p53 (pAb 1801 mAb) and TS (TS106 mAb) expression on formalin-fixed paraffin-embedded primary tumour specimens was related to probability of clinical response to chemotherapy, time to progression and overall survival. p53 was expressed in 53/108 (49%) tumours, while 54/108 (50%) showed TS immunostaining. No relationship was demonstrated between p53 positivity and clinical response to chemotherapy (objective response (OR): 20% vs 23%, in p53+ and p53- cases respectively) or overall survival. Percent of OR was significantly higher in TS-negative with respect to TS-positive tumours (30% vs 15% respectively; P < 0.04); simultaneous analysis of TS and p53 indicated 7% OR for p53-positive/TS-positive tumours vs 46% for p53-positive/TS-negative tumours (P < 0.03). Logistic regression analysis confirmed a significant association between TS tumour status and clinical response to chemotherapy (hazard ratio (HR): 2.91; 95% confidence interval (CI) 8.34-1.01; two-sided P < 0.05). A multivariate analysis of overall survival showed that only a small number of metastatic sites was statistically relevant (HR 1.89; 95% CI 2.85-1.26; two-sided P < 0.03). Our study suggests that immunohistochemical expression of p53 and TS could assist the clinician in predicting response of colorectal cancer patients to modulated MTX-5-FU therapy.
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pubmed:commentsCorrections |
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10682666-9816112
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0007-0920
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pubmed:author |
pubmed-author:AllegraC JCJ,
pubmed-author:De LenaMM,
pubmed-author:JohnstonP GPG,
pubmed-author:LacavaJJ,
pubmed-author:LeoneBB,
pubmed-author:MachiavelliMM,
pubmed-author:ParadisoAA,
pubmed-author:PetroniSS,
pubmed-author:RomeroAA,
pubmed-author:SimoneGG,
pubmed-author:VallejoCC
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pubmed:issnType |
Print
|
pubmed:volume |
82
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
560-7
|
pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10682666-Adult,
pubmed-meshheading:10682666-Aged,
pubmed-meshheading:10682666-Antineoplastic Agents,
pubmed-meshheading:10682666-Colorectal Neoplasms,
pubmed-meshheading:10682666-Humans,
pubmed-meshheading:10682666-Immunohistochemistry,
pubmed-meshheading:10682666-Middle Aged,
pubmed-meshheading:10682666-Neoplasm Metastasis,
pubmed-meshheading:10682666-Prognosis,
pubmed-meshheading:10682666-Thymidylate Synthase,
pubmed-meshheading:10682666-Treatment Outcome,
pubmed-meshheading:10682666-Tumor Suppressor Protein p53
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pubmed:year |
2000
|
pubmed:articleTitle |
Thymidilate synthase and p53 primary tumour expression as predictive factors for advanced colorectal cancer patients.
|
pubmed:affiliation |
Clinical Experimental Oncology Laboratory, Oncology Institute, Bari, Italy. anpara@tin.it
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|