| pubmed-article:10682663 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10682663 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:10682663 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:10682663 | lifeskim:mentions | umls-concept:C0008669 | lld:lifeskim |
| pubmed-article:10682663 | lifeskim:mentions | umls-concept:C0449721 | lld:lifeskim |
| pubmed-article:10682663 | lifeskim:mentions | umls-concept:C1880274 | lld:lifeskim |
| pubmed-article:10682663 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:10682663 | lifeskim:mentions | umls-concept:C1553877 | lld:lifeskim |
| pubmed-article:10682663 | lifeskim:mentions | umls-concept:C1608885 | lld:lifeskim |
| pubmed-article:10682663 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10682663 | pubmed:dateCreated | 2000-3-2 | lld:pubmed |
| pubmed-article:10682663 | pubmed:abstractText | Chromosome 6 deletions are common in human neoplasms including gliomas. In order to study the frequency and identify commonly deleted regions of chromosome 6 in astrocytomas, 159 tumours (106 glioblastomas, 39 anaplastic astrocytomas and 14 astrocytomas malignancy grade II) were analysed using 31 microsatellite markers that span the chromosome. Ninety-five per cent of cases with allelic losses had losses affecting 6q. Allelic losses were infrequent in astrocytomas malignancy grade II (14%) but more usual in anaplastic astrocytomas (38%) and glioblastomas (37%). Evidence for clonal heterogeneity in the astrocytomas and anaplastic astrocytomas was frequently observed (i.e. co-existence of subpopulations with and without chromosome 6 deletions). Clonal heterogeneity was less common in glioblastomas. Five commonly deleted regions were identified on 6q. These observations suggest that a number of tumour suppressor genes are located on 6q and that these genes may be involved in the progression of astrocytic tumours. | lld:pubmed |
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| pubmed-article:10682663 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10682663 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10682663 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10682663 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10682663 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10682663 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:10682663 | pubmed:author | pubmed-author:MiyakawaAA | lld:pubmed |
| pubmed-article:10682663 | pubmed:author | pubmed-author:SchmidtE EEE | lld:pubmed |
| pubmed-article:10682663 | pubmed:author | pubmed-author:CollinsV PVP | lld:pubmed |
| pubmed-article:10682663 | pubmed:author | pubmed-author:IchimuraKK | lld:pubmed |
| pubmed-article:10682663 | pubmed:author | pubmed-author:Varmeh-ZiaieS... | lld:pubmed |
| pubmed-article:10682663 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10682663 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:10682663 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10682663 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10682663 | pubmed:pagination | 543-9 | lld:pubmed |
| pubmed-article:10682663 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10682663 | pubmed:meshHeading | pubmed-meshheading:10682663... | lld:pubmed |
| pubmed-article:10682663 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10682663 | pubmed:articleTitle | Multiple deleted regions on the long arm of chromosome 6 in astrocytic tumours. | lld:pubmed |
| pubmed-article:10682663 | pubmed:affiliation | Department of Pathology, University of Cambridge, Addenbrooke's Hospital, UK. | lld:pubmed |
| pubmed-article:10682663 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10682663 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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