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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-3-2
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pubmed:abstractText |
Chromosome 6 deletions are common in human neoplasms including gliomas. In order to study the frequency and identify commonly deleted regions of chromosome 6 in astrocytomas, 159 tumours (106 glioblastomas, 39 anaplastic astrocytomas and 14 astrocytomas malignancy grade II) were analysed using 31 microsatellite markers that span the chromosome. Ninety-five per cent of cases with allelic losses had losses affecting 6q. Allelic losses were infrequent in astrocytomas malignancy grade II (14%) but more usual in anaplastic astrocytomas (38%) and glioblastomas (37%). Evidence for clonal heterogeneity in the astrocytomas and anaplastic astrocytomas was frequently observed (i.e. co-existence of subpopulations with and without chromosome 6 deletions). Clonal heterogeneity was less common in glioblastomas. Five commonly deleted regions were identified on 6q. These observations suggest that a number of tumour suppressor genes are located on 6q and that these genes may be involved in the progression of astrocytic tumours.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10682663-10560660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10682663-1283325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10682663-1551072,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
543-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10682663-Astrocytoma,
pubmed-meshheading:10682663-Brain Neoplasms,
pubmed-meshheading:10682663-Centromere,
pubmed-meshheading:10682663-Chromosome Deletion,
pubmed-meshheading:10682663-Chromosomes, Human, Pair 6,
pubmed-meshheading:10682663-DNA, Satellite,
pubmed-meshheading:10682663-Disease Progression,
pubmed-meshheading:10682663-Humans,
pubmed-meshheading:10682663-Telomere
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pubmed:year |
2000
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pubmed:articleTitle |
Multiple deleted regions on the long arm of chromosome 6 in astrocytic tumours.
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pubmed:affiliation |
Department of Pathology, University of Cambridge, Addenbrooke's Hospital, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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