| pubmed-article:10681419 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:10681419 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:10681419 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10681419 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10681419 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
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| pubmed-article:10681419 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10681419 | pubmed:dateCreated | 2000-4-11 | lld:pubmed |
| pubmed-article:10681419 | pubmed:abstractText | We have developed a thin-slice preparation of whole rat carotid body that allows us to perform patch-clamp recording of membrane ionic currents and to monitor catecholamine secretion by amperometry in single glomus cells under direct visual control. In normoxic conditions (P(O(2)) approximately 140 mmHg; 1 mmHg = 133 Pa), most glomus cells did not have measurable secretory activity, but exposure to hypoxia (P(O(2)) approximately 20 mmHg) elicited the appearance of a large number of spike-like exocytotic events. This neurosecretory response to hypoxia was fully reversible and required extracellular Ca(2+) influx. The average charge of single quantal events was 46 +/- 25 fC (n = 218), which yields an estimate of approximately 140,000 catecholamine molecules per vesicle. Addition of tetraethylammonium (TEA; 2-5 mM) to the extracellular solution induced in most (>95%) cells tested (n = 32) a secretory response similar to that elicited by low P(O(2)). Cells nonresponsive to hypoxia but activated by exposure to high external K(+) were also stimulated by TEA. A secretory response similar to the responses to hypoxia and TEA was also observed after treatment of the cells with iberiotoxin to block selectively Ca(2+)- and voltage-activated maxi-K(+) channels. Our data further show that membrane ion channels are critically involved in sensory transduction in the carotid body. We also show that in intact glomus cells inhibition of voltage-dependent K(+) channels can contribute to initiation of the secretory response to low P(O(2)). | lld:pubmed |
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| pubmed-article:10681419 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10681419 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10681419 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10681419 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10681419 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10681419 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10681419 | pubmed:author | pubmed-author:Lopez-BarneoJ... | lld:pubmed |
| pubmed-article:10681419 | pubmed:author | pubmed-author:LudewigUU | lld:pubmed |
| pubmed-article:10681419 | pubmed:author | pubmed-author:PardalRR | lld:pubmed |
| pubmed-article:10681419 | pubmed:author | pubmed-author:Garcia-Hirsch... | lld:pubmed |
| pubmed-article:10681419 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10681419 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:10681419 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:10681419 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10681419 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10681419 | pubmed:pagination | 2361-6 | lld:pubmed |
| pubmed-article:10681419 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10681419 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10681419 | pubmed:articleTitle | Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium. | lld:pubmed |
| pubmed-article:10681419 | pubmed:affiliation | Departamento de Fisiologia, Facultad de Medicina y Hospital Universitario Virgen del Rocio, Universidad de Sevilla, E-41009, Sevilla, Spain. | lld:pubmed |
| pubmed-article:10681419 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10681419 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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