Linked Life Data

10679770

Source:http://linkedlifedata.com/resource/pubmed/id/10679770

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-3-16
pubmed:abstractText
Trophic factors, such as the neurotrophins, CNTF, and GDNF, represent unique families of proteins that are essential for the development of the vertebrate nervous system. Surprisingly, there is little evidence to date that these proteins exist in Drosophila melanogaster and Caenorhabditis elegans, even though other polypeptide growth factors, such as EGF, FGF, and insulin, are conserved in these species. For the neurotrophins, the evolution of NGF, BDNF, NT-3, and NT-4 as a family implies that these signaling molecules may be involved in mediating additional neural activities, such as learning, memory, and behavior. Indeed, there is abundant evidence now that BDNF is involved in synapse modification, neurotransmitter release, long-term potentiation, and mechanosensation. The widening scope of neurotrophin action will require more physiological, genomic, and integrative approaches to understand fully the mechanisms by which survival factors can mediate so many diverse effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0360-4012
pubmed:author
pubmed:copyrightInfo
Copyright 2000 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
353-5
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Trophic factors: An evolutionary cul-de-sac or door into higher neuronal function?
pubmed:affiliation
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology and Physiology & Neuroscience, New York University School of Medicine, New York, NY 10016, USA. chao@saturn.med.nyu.edu
pubmed:publicationType
Journal Article, Review