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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-3-22
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pubmed:abstractText |
Lymphotactin is unique among chemokines in that it contains only two of four conserved cysteines and may possess a structure less constrained than other chemokines. The viral chemokine vMIP-II, which presumably has a structure similar to that of CC chemokines has been shown to inhibit many chemokine receptors, but its activity at GPR5/XCR1 has not been described. Interestingly, vMIP-II (but not vMIP-I) was found to be a potent antagonist of lymphotactin activity at GPR5/XCR1, extending the range of chemokine classes that this viral protein is known to inhibit to include the C class chemokine. In addition, we have extended previous analyses of GPR5/XCR1 expression and show that this receptor is expressed in leukocyte cells previously shown to be responsive to lymphotactin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, C,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Inflammatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/XCL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/XCR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Xcl1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/lymphotactin,
http://linkedlifedata.com/resource/pubmed/chemical/vMIP-II
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
268
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
938-41
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pubmed:dateRevised |
2008-5-6
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pubmed:meshHeading |
pubmed-meshheading:10679309-Animals,
pubmed-meshheading:10679309-Base Sequence,
pubmed-meshheading:10679309-Calcium,
pubmed-meshheading:10679309-Cell Line,
pubmed-meshheading:10679309-Chemokines,
pubmed-meshheading:10679309-Chemokines, C,
pubmed-meshheading:10679309-Cloning, Molecular,
pubmed-meshheading:10679309-DNA Primers,
pubmed-meshheading:10679309-Gene Expression,
pubmed-meshheading:10679309-Humans,
pubmed-meshheading:10679309-Ligands,
pubmed-meshheading:10679309-Lymphokines,
pubmed-meshheading:10679309-Macrophage Inflammatory Proteins,
pubmed-meshheading:10679309-Membrane Proteins,
pubmed-meshheading:10679309-Mice,
pubmed-meshheading:10679309-Receptors, Cell Surface,
pubmed-meshheading:10679309-Receptors, G-Protein-Coupled,
pubmed-meshheading:10679309-Recombinant Proteins,
pubmed-meshheading:10679309-Sialoglycoproteins,
pubmed-meshheading:10679309-Tissue Distribution,
pubmed-meshheading:10679309-Viral Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
Identification of viral macrophage inflammatory protein (vMIP)-II as a ligand for GPR5/XCR1.
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pubmed:affiliation |
Human Genome Research, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA.
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pubmed:publicationType |
Journal Article
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