| pubmed-article:10679281 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10679281 | lifeskim:mentions | umls-concept:C0560175 | lld:lifeskim |
| pubmed-article:10679281 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:10679281 | lifeskim:mentions | umls-concept:C0074129 | lld:lifeskim |
| pubmed-article:10679281 | lifeskim:mentions | umls-concept:C0001060 | lld:lifeskim |
| pubmed-article:10679281 | lifeskim:mentions | umls-concept:C0011209 | lld:lifeskim |
| pubmed-article:10679281 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10679281 | lifeskim:mentions | umls-concept:C1706209 | lld:lifeskim |
| pubmed-article:10679281 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:10679281 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10679281 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:10679281 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10679281 | pubmed:dateCreated | 2000-3-22 | lld:pubmed |
| pubmed-article:10679281 | pubmed:abstractText | We have shown that muramyl dipeptide (MDP) conjugated to a 10-mer polyguanylic acid (PolyG) is specifically internalized by macrophages through scavenger receptor (SCR)-mediated endocytosis. Macrophages activated by PolyG-MDP displayed about 20-fold higher cytotoxic activity against nonmacrophage tumor cells compared to that elicited by free MDP. The PolyG-MDP was found to trigger the secretion of higher levels of interleukin-6, interleukin-1alpha, TNF-alpha, and nitric oxide in comparison to free MDP. Addition of antibodies directed against IL-6 and TNF-alpha to macrophage culture completely abrogated the tumoricidal response of PolyG-MDP, indicating that these two cytokines are primarily responsible for bioefficacy. This general approach of PolyG as a vehicle may find wide application in the delivery of genes and antisense oligonucleotides to macrophages. | lld:pubmed |
| pubmed-article:10679281 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10679281 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10679281 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10679281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10679281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10679281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10679281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10679281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10679281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10679281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10679281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10679281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10679281 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10679281 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10679281 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:10679281 | pubmed:author | pubmed-author:BasuS KSK | lld:pubmed |
| pubmed-article:10679281 | pubmed:author | pubmed-author:MukhopadhyayA... | lld:pubmed |
| pubmed-article:10679281 | pubmed:author | pubmed-author:RoyR PRP | lld:pubmed |
| pubmed-article:10679281 | pubmed:author | pubmed-author:SrividyaSS | lld:pubmed |
| pubmed-article:10679281 | pubmed:copyrightInfo | Copyright 2000 Academic Press. | lld:pubmed |
| pubmed-article:10679281 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10679281 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:10679281 | pubmed:volume | 268 | lld:pubmed |
| pubmed-article:10679281 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10679281 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10679281 | pubmed:pagination | 772-7 | lld:pubmed |
| pubmed-article:10679281 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10679281 | pubmed:meshHeading | pubmed-meshheading:10679281... | lld:pubmed |
| pubmed-article:10679281 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10679281 | pubmed:articleTitle | Selective activation of antitumor activity of macrophages by the delivery of muramyl dipeptide using a novel polynucleotide-based carrier recognized by scavenger receptors. | lld:pubmed |
| pubmed-article:10679281 | pubmed:affiliation | National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, India. | lld:pubmed |
| pubmed-article:10679281 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10679281 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:10679281 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10679281 | lld:pubmed |
