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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1979-5-23
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pubmed:abstractText |
Cephapirin was utilized to examine the interaction of beta-lactam antibiotics with growing Bacillus subtilis cells and the biological effects simultaneously produced. Saturation binding and quantitative cell death were observed at the cephapirin concentration of 0.1 mug/ml. Cephapirin bound to all penicillin-binding proteins except the d-alanine carboxypeptidase. A specific [(14)C]benzylpenicillin-binding assay was developed for the d-alanine carboxypeptidase. At the lowest saturating concentration of antibiotic (0.1 mug/ml), cephapirin inhibited formation of the d-alanine carboxypeptidase. Upon incubation with cephapirin, 18% of the membranous d-alanine carboxypeptidase was released into the media. The data suggest that beta-lactam antibiotics may affect the formation of bacterial cytoplasmic membranes in addition to their effect on cell wall synthesis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/106774-1091862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/106774-1103132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/106774-13303921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/106774-14240539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/106774-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/106774-4126817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/106774-4204441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/106774-4212230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/106774-4217587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/106774-4344991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/106774-4593965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/106774-4608953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/106774-4850204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/106774-4988528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/106774-6033778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/106774-808545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/106774-819927
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
204-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1979
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pubmed:articleTitle |
Effect of cephapirin on formation of D-alanine carboxypeptidase in growing Bacillus subtilis cells.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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