Linked Life Data

10675792

Source:http://linkedlifedata.com/resource/pubmed/id/10675792

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-4-7
pubmed:abstractText
We examined the 5-hydroxytryptamine (5-HT)-induced locomotor rhythm in isolated spinal cord preparations taken from neonatal mice on postnatal day (P) 0-3. Motor activity was recorded from L2 and L5 ventral roots. Bath application of 5-HT (15-100 microM) evoked rhythmic bursts that alternated between the two sides, and the bursts in the L2 ventral root alternated with those in the ipsilateral L5 ventral root. After transection of the mid-lumbar cord, the locomotor rhythm in L2 persisted, while that in the L5 ventral root was abolished. This suggests that the upper lumbar region has a greater ability to generate a locomotor rhythm than the lower lumbar spinal cord. Kynurenate, a broad-spectrum glutamate receptor antagonist, blocked the 5-HT-induced locomotor rhythm indicating that ionotropic glutamate receptors are required for the rhythm to be generated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
280
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
187-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
5-Hydroxytryptamine-induced locomotor rhythm in the neonatal mouse spinal cord in vitro.
pubmed:affiliation
Department of Physiology, Institute of Basic Medical Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki, Japan. nishimar@md.tsukuba.ac.jp
pubmed:publicationType
Journal Article, In Vitro