Linked Life Data

10673775

Source:http://linkedlifedata.com/resource/pubmed/id/10673775

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-3-17
pubmed:abstractText
Dopamine D4 receptor (DRD4), serotonin transporter promoter regulatory region (5-HTTLPR) and catechol O-methyltransferase (COMT) polymorphisms were examined for association with TPQ personality factors in 455 subjects. Significant interactions were observed by multivariate analysis, (COMT x 5-HTTLPR: Hotelling's Trace = 2.3, P = 0.02) and by subsequent univariate 3-way ANOVA when Novelty Seeking (NS) was the dependent variable: 5-HTTLPR x D4DR (F = 6.18, P = 0.03) and COMT x 5-HTTLPR (F = 4.42, P = 0.03). In the absence of the short 5-HTTLPR allele and in the presence of the high enzyme activity COMT val/val genotype, NS scores are higher in the presence of the DRD4 seven-repeat allele. The effect of these three polymorphisms on NS was also examined using a within-families design. Siblings who shared identical genotype groups for all three polymorphisms (COMT, DRD4 and 5-HTTLPR) had significantly correlated NS scores (intraclass coefficient = 0.39, F = 2.26, P = 0.008, n = 49) whereas sibs with dissimilar genotypes in at least one polymorphism showed no significant correlation for NS scores (intraclass coefficient = 0.177, F = 1.43, P = 0.09, n = 110). Similar interactions were also observed between these three polymorphisms and Novelty Seeking when the 150 independently recruited and non-related subjects were analyzed. The current results are consistent with two earlier reports in which we demonstrated an interaction between the 5-HTTLPR and DRD4 polymorphisms in 2-week-old neonates, in the same children assessed again at 2 months of age and in adults. Molecular Psychiatry (2000) 5, 96-100.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1359-4184
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
96-100
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:10673775-Adolescent, pubmed-meshheading:10673775-Adult, pubmed-meshheading:10673775-Brain, pubmed-meshheading:10673775-Brain Chemistry, pubmed-meshheading:10673775-Carrier Proteins, pubmed-meshheading:10673775-Catechol O-Methyltransferase, pubmed-meshheading:10673775-Exploratory Behavior, pubmed-meshheading:10673775-Female, pubmed-meshheading:10673775-Genotype, pubmed-meshheading:10673775-Humans, pubmed-meshheading:10673775-Male, pubmed-meshheading:10673775-Membrane Glycoproteins, pubmed-meshheading:10673775-Membrane Transport Proteins, pubmed-meshheading:10673775-Nerve Tissue Proteins, pubmed-meshheading:10673775-Nuclear Family, pubmed-meshheading:10673775-Personality, pubmed-meshheading:10673775-Polymorphism, Genetic, pubmed-meshheading:10673775-Promoter Regions, Genetic, pubmed-meshheading:10673775-Questionnaires, pubmed-meshheading:10673775-Receptors, Dopamine D2, pubmed-meshheading:10673775-Receptors, Dopamine D4, pubmed-meshheading:10673775-Serotonin Plasma Membrane Transport Proteins
pubmed:year
2000
pubmed:articleTitle
Association between tridimensional personality questionnaire (TPQ) traits and three functional polymorphisms: dopamine receptor D4 (DRD4), serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT).
pubmed:affiliation
Faculty of Health Sciences, Ben Gurion University of the Negev, Israel.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't