Source:http://linkedlifedata.com/resource/pubmed/id/10673731
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2000-3-15
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| pubmed:abstractText |
The possible association between the insertion/deletion (I/D) polymorphism of the angiotensin I converting enzyme (ACE) gene and left ventricular hypertrophy (LVH) was investigated in a group of essential hypertensive patients. Seventy-one essential hypertensive patients (35 men and 36 women), aged 51 +/- 1 years, were genotyped by PCR for the I/D polymorphism of the ACE gene. Cardiac morphology and function were assessed by means of M-mode echocardiography. The relative frequencies of the three genotypes, DD, DI, and II, were respectively: 24%, 55%, and 21%. Mean values of left ventricular mass index were 145, 144, and 150 g/m2 for DD, DI, and II genotypes, without significant differences among them (P = 0.82). Likewise, the prevalence of LVH (76%, 64%, and 87%) was not significantly different among the three genotypes (P = 0.23). We conclude that the ACE gene I/D polymorphism is not associated with LVH in essential hypertension. Journal of Human Hypertension (2000) 14, 47-49.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0950-9240
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
14
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
47-9
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10673731-Adolescent,
pubmed-meshheading:10673731-Adult,
pubmed-meshheading:10673731-Aged,
pubmed-meshheading:10673731-Blood Pressure,
pubmed-meshheading:10673731-Cross-Sectional Studies,
pubmed-meshheading:10673731-DNA,
pubmed-meshheading:10673731-DNA Transposable Elements,
pubmed-meshheading:10673731-Echocardiography,
pubmed-meshheading:10673731-Female,
pubmed-meshheading:10673731-Gene Deletion,
pubmed-meshheading:10673731-Genetic Markers,
pubmed-meshheading:10673731-Genotype,
pubmed-meshheading:10673731-Heart Ventricles,
pubmed-meshheading:10673731-Humans,
pubmed-meshheading:10673731-Hypertension,
pubmed-meshheading:10673731-Hypertrophy, Left Ventricular,
pubmed-meshheading:10673731-Male,
pubmed-meshheading:10673731-Middle Aged,
pubmed-meshheading:10673731-Peptidyl-Dipeptidase A,
pubmed-meshheading:10673731-Polymorphism, Genetic,
pubmed-meshheading:10673731-Stroke Volume
|
| pubmed:year |
2000
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| pubmed:articleTitle |
Lack of association between ACE gene polymorphism and left ventricular hypertrophy in essential hypertension.
|
| pubmed:affiliation |
Department of Internal Medicine, Hospital Clínic, Barcelona, Spain.
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| pubmed:publicationType |
Journal Article,
Comparative Study
|