| pubmed-article:10673508 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10673508 | lifeskim:mentions | umls-concept:C0812201 | lld:lifeskim |
| pubmed-article:10673508 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:10673508 | lifeskim:mentions | umls-concept:C1148673 | lld:lifeskim |
| pubmed-article:10673508 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10673508 | pubmed:dateCreated | 2000-3-17 | lld:pubmed |
| pubmed-article:10673508 | pubmed:abstractText | Phosphorylation of transcription factors is a key link between cell signaling and the control of gene expression. Here we report that phosphorylation regulates DNA binding of the Ets-1 transcription factor by reinforcing an autoinhibitory mechanism. Quantitative DNA-binding assays show that calcium-dependent phosphorylation inhibits Ets-1 DNA binding 50-fold. The four serines that mediate this inhibitory effect are distant from the DNA-binding domain but near structural elements required for autoinhibition. Mutational analyses demonstrate that an intact inhibitory module is required for phosphorylation-dependent regulation. Partial proteolysis studies indicate that phosphorylation stabilizes an inhibitory conformation. These findings provide a structural mechanism for phosphorylation-dependent inhibition of Ets-1 DNA binding and demonstrate a new function for inhibitory modules as structural mediators of negative signaling events. | lld:pubmed |
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| pubmed-article:10673508 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10673508 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10673508 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10673508 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10673508 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:10673508 | pubmed:author | pubmed-author:GravesB JBJ | lld:pubmed |
| pubmed-article:10673508 | pubmed:author | pubmed-author:CowleyD ODO | lld:pubmed |
| pubmed-article:10673508 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10673508 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10673508 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:10673508 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10673508 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10673508 | pubmed:pagination | 366-76 | lld:pubmed |
| pubmed-article:10673508 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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