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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-3-15
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pubmed:databankReference |
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pubmed:abstractText |
[corrected] The Staphylococcus aureus collagen-binding protein Cna mediates bacterial adherence to collagen. The primary sequence of Cna has a non-repetitive collagen-binding A region, followed by the repetitive B region. The B region has one to four 23 kDa repeat units (B(1)-B(4)), depending on the strain of origin. The affinity of the A region for collagen is independent of the B region. However, the B repeat units have been suggested to serve as a 'stalk' that projects the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. To understand the biological role of these B-region repeats we determined their three-dimensional structure.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0969-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-78
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10673425-Adhesins, Bacterial,
pubmed-meshheading:10673425-Amino Acid Sequence,
pubmed-meshheading:10673425-Bacterial Proteins,
pubmed-meshheading:10673425-Collagen,
pubmed-meshheading:10673425-Crystallography, X-Ray,
pubmed-meshheading:10673425-Immunoglobulin G,
pubmed-meshheading:10673425-Models, Molecular,
pubmed-meshheading:10673425-Molecular Sequence Data,
pubmed-meshheading:10673425-Protein Conformation,
pubmed-meshheading:10673425-Protein Folding,
pubmed-meshheading:10673425-Protein Structure, Tertiary,
pubmed-meshheading:10673425-Repetitive Sequences, Amino Acid,
pubmed-meshheading:10673425-Sequence Deletion,
pubmed-meshheading:10673425-Sequence Homology, Amino Acid,
pubmed-meshheading:10673425-Staphylococcus aureus,
pubmed-meshheading:10673425-Static Electricity
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pubmed:year |
2000
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pubmed:articleTitle |
Novel fold and assembly of the repetitive B region of the Staphylococcus aureus collagen-binding surface protein.
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pubmed:affiliation |
Center for Macromolecular Crystallography, School of Optometry, University of Alabama at Birmingham, Birmingham, AL 35294-0005, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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