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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-3-7
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pubmed:abstractText |
Among the hapalosin derivatives synthesized, the compounds carrying methyl (5a), methylthioethyl (5d) and phenylmethyl (5e) groups at the C12 position possess only the cis-peptide structure, in contrast to the cases of 5b and 5c. In addition to their conformational stability, the biological activities of the compounds were determined in relation of the P-glycoprotein-mediated MDR-reversing activity and induction of apoptosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
101-3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10673089-Antineoplastic Agents,
pubmed-meshheading:10673089-Apoptosis,
pubmed-meshheading:10673089-Depsipeptides,
pubmed-meshheading:10673089-Drug Resistance, Multiple,
pubmed-meshheading:10673089-Lactams,
pubmed-meshheading:10673089-Lactones,
pubmed-meshheading:10673089-Models, Molecular,
pubmed-meshheading:10673089-Molecular Conformation,
pubmed-meshheading:10673089-Molecular Structure,
pubmed-meshheading:10673089-Peptides, Cyclic,
pubmed-meshheading:10673089-Protein Conformation,
pubmed-meshheading:10673089-Tumor Cells, Cultured,
pubmed-meshheading:10673089-Vincristine
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pubmed:year |
2000
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pubmed:articleTitle |
Synthesis and biological activities of hapalosin derivatives with modification at the C12 position.
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pubmed:affiliation |
Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi, Yokohama, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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