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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-2-15
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pubmed:abstractText |
Stromal keratitis is an immunopathologic consequence of herpes simplex virus (HSV) infection of the cornea. The lesion is immunopathologic, but the identities of molecules that drive the reaction remain unresolved. To exclude viral antigen recognition as a necessary step in the disease process, ocular HSV infection was followed in Tg-RAG mice (OVA-TCR transgenic mice crossed to RAG2-deficient mice) whose limited T-cell repertoire did not include immune responsiveness to HSV.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
453-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10670475-Animals,
pubmed-meshheading:10670475-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10670475-Corneal Stroma,
pubmed-meshheading:10670475-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10670475-Herpesvirus 1, Human,
pubmed-meshheading:10670475-Immunoenzyme Techniques,
pubmed-meshheading:10670475-Immunoglobulin G,
pubmed-meshheading:10670475-Interferon-gamma,
pubmed-meshheading:10670475-Keratitis, Herpetic,
pubmed-meshheading:10670475-Lymphocyte Activation,
pubmed-meshheading:10670475-Lymphocyte Depletion,
pubmed-meshheading:10670475-Mice,
pubmed-meshheading:10670475-Mice, Inbred BALB C,
pubmed-meshheading:10670475-Mice, Transgenic,
pubmed-meshheading:10670475-Molecular Mimicry,
pubmed-meshheading:10670475-Ovalbumin,
pubmed-meshheading:10670475-RNA,
pubmed-meshheading:10670475-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2000
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pubmed:articleTitle |
Bystander activation of CD4+ T cells accounts for herpetic ocular lesions.
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pubmed:affiliation |
Department of Microbiology, College of Veterinary Medicine, The University of Tennessee, Knoxville 37996-0845, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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