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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5455
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pubmed:dateCreated |
2000-2-24
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pubmed:abstractText |
Phosphoinositide 3-kinase (PI3K) activity is crucial for leukocyte function, but the roles of the four receptor-activated isoforms are unclear. Mice lacking heterotrimeric guanine nucleotide-binding protein (G protein)-coupled PI3Kgamma were viable and had fully differentiated neutrophils and macrophages. Chemoattractant-stimulated PI3Kgamma-/- neutrophils did not produce phosphatidylinositol 3,4,5-trisphosphate, did not activate protein kinase B, and displayed impaired respiratory burst and motility. Peritoneal PI3Kgamma-null macrophages showed a reduced migration toward a wide range of chemotactic stimuli and a severely defective accumulation in a septic peritonitis model. These results demonstrate that PI3Kgamma is a crucial signaling molecule required for macrophage accumulation in inflammation.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
287
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1049-53
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10669418-Animals,
pubmed-meshheading:10669418-Chemotactic Factors,
pubmed-meshheading:10669418-Chemotaxis,
pubmed-meshheading:10669418-Chemotaxis, Leukocyte,
pubmed-meshheading:10669418-Enzyme Activation,
pubmed-meshheading:10669418-Gene Targeting,
pubmed-meshheading:10669418-Heterotrimeric GTP-Binding Proteins,
pubmed-meshheading:10669418-Isoenzymes,
pubmed-meshheading:10669418-Macrophages, Peritoneal,
pubmed-meshheading:10669418-Mice,
pubmed-meshheading:10669418-Mice, Inbred C57BL,
pubmed-meshheading:10669418-Mice, Knockout,
pubmed-meshheading:10669418-Neutrophils,
pubmed-meshheading:10669418-Peritonitis,
pubmed-meshheading:10669418-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:10669418-Phosphatidylinositol Phosphates,
pubmed-meshheading:10669418-Protein-Serine-Threonine Kinases,
pubmed-meshheading:10669418-Proto-Oncogene Proteins,
pubmed-meshheading:10669418-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:10669418-Respiratory Burst,
pubmed-meshheading:10669418-Signal Transduction
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pubmed:year |
2000
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pubmed:articleTitle |
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.
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pubmed:affiliation |
Department of Genetics, Biology and Biochemistry, University of Torino, Turin, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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