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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5455
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pubmed:dateCreated |
2000-2-24
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pubmed:abstractText |
The roles of phosphoinositide 3-kinase (PI3K) and phospholipase C (PLC) in chemoattractant-elicited responses were studied in mice lacking these key enzymes. PI3Kgamma was required for chemoattractant-induced production of phosphatidylinositol 3,4,5-trisphosphate [PtdIns (3,4,5)P3] and has an important role in chemoattractant-induced superoxide production and chemotaxis in mouse neutrophils and in production of T cell-independent antigen-specific antibodies composed of the immunoglobulin lambda light chain (TI-IglambdaL). The study of the mice lacking PLC-beta2 and -beta3 revealed that the PLC pathways have an important role in chemoattractant-mediated production of superoxide and regulation of protein kinases, but not chemotaxis. The PLC pathways also appear to inhibit the chemotactic activity induced by certain chemoattractants and to suppress TI-IglambdaL production.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL4,
http://linkedlifedata.com/resource/pubmed/chemical/Chemotactic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin lambda-Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Inflammatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/N-Formylmethionine...,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipase C beta,
http://linkedlifedata.com/resource/pubmed/chemical/Plcb2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Plcb3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxides,
http://linkedlifedata.com/resource/pubmed/chemical/Type C Phospholipases,
http://linkedlifedata.com/resource/pubmed/chemical/phosphatidylinositol...
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
287
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1046-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10669417-Animals,
pubmed-meshheading:10669417-B-Lymphocytes,
pubmed-meshheading:10669417-Chemokine CCL4,
pubmed-meshheading:10669417-Chemotactic Factors,
pubmed-meshheading:10669417-Chemotaxis, Leukocyte,
pubmed-meshheading:10669417-Immunoglobulin lambda-Chains,
pubmed-meshheading:10669417-Isoenzymes,
pubmed-meshheading:10669417-Macrophage Inflammatory Proteins,
pubmed-meshheading:10669417-Mice,
pubmed-meshheading:10669417-N-Formylmethionine Leucyl-Phenylalanine,
pubmed-meshheading:10669417-Neutrophil Infiltration,
pubmed-meshheading:10669417-Neutrophils,
pubmed-meshheading:10669417-Peritonitis,
pubmed-meshheading:10669417-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:10669417-Phosphatidylinositol Phosphates,
pubmed-meshheading:10669417-Phospholipase C beta,
pubmed-meshheading:10669417-Phosphorylation,
pubmed-meshheading:10669417-Signal Transduction,
pubmed-meshheading:10669417-Skin Ulcer,
pubmed-meshheading:10669417-Superoxides,
pubmed-meshheading:10669417-Type C Phospholipases
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pubmed:year |
2000
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pubmed:articleTitle |
Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction.
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pubmed:affiliation |
Department of Pharmacology, University of Rochester, Rochester, NY 14642, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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