| pubmed-article:10669261 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10669261 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:10669261 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:10669261 | lifeskim:mentions | umls-concept:C0032098 | lld:lifeskim |
| pubmed-article:10669261 | lifeskim:mentions | umls-concept:C1049770 | lld:lifeskim |
| pubmed-article:10669261 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:10669261 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10669261 | pubmed:dateCreated | 2000-3-16 | lld:pubmed |
| pubmed-article:10669261 | pubmed:abstractText | A polysaccharide extracted from the leaf of Rhizophora apiculata (RAP) was assessed in cell culture systems, for its activity against human and simian immunodeficiency viruses. RAP inhibited HIV-1 or HIV-2 or SIV strains in various cell cultures and assay systems. It blocked the expression of HIV-1 antigen in MT-4 cells and abolished the production of HIV-1 p24 antigen in peripheral blood mononuclear cells (PBMC); the 50% effective concentration (EC50) of RAP in HIV-1 infected MT-4 cells and in PBMC was 10.7 and 25.9 microg/ml, respectively. RAP (100 microg/ml) completely blocked the binding of HIV-1 virions to MT-4 cells. RAP also reduced the production of viral mRNA when added before virus adsorption. RAP inhibited syncytium formation in cocultures of MOLT-4 cells and MOLT-4/HIV-1(IIIB) cells. RAP did not prolong activated partial thromboplastin time (APTT) up to 500 microg/ml. These properties may be advantageous should RAP be considered for further development. | lld:pubmed |
| pubmed-article:10669261 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10669261 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10669261 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10669261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10669261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10669261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10669261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10669261 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10669261 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10669261 | pubmed:issn | 0166-3542 | lld:pubmed |
| pubmed-article:10669261 | pubmed:author | pubmed-author:NakanoMM | lld:pubmed |
| pubmed-article:10669261 | pubmed:author | pubmed-author:YamamotoNN | lld:pubmed |
| pubmed-article:10669261 | pubmed:author | pubmed-author:IzumiHH | lld:pubmed |
| pubmed-article:10669261 | pubmed:author | pubmed-author:NakashimaHH | lld:pubmed |
| pubmed-article:10669261 | pubmed:author | pubmed-author:ArakakiRR | lld:pubmed |
| pubmed-article:10669261 | pubmed:author | pubmed-author:KathiresanKK | lld:pubmed |
| pubmed-article:10669261 | pubmed:author | pubmed-author:PremanathanMM | lld:pubmed |
| pubmed-article:10669261 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10669261 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10669261 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:10669261 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10669261 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10669261 | pubmed:pagination | 113-22 | lld:pubmed |
| pubmed-article:10669261 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10669261 | pubmed:meshHeading | pubmed-meshheading:10669261... | lld:pubmed |
| pubmed-article:10669261 | pubmed:meshHeading | pubmed-meshheading:10669261... | lld:pubmed |
| pubmed-article:10669261 | pubmed:meshHeading | pubmed-meshheading:10669261... | lld:pubmed |
| pubmed-article:10669261 | pubmed:meshHeading | pubmed-meshheading:10669261... | lld:pubmed |
| pubmed-article:10669261 | pubmed:meshHeading | pubmed-meshheading:10669261... | lld:pubmed |
| pubmed-article:10669261 | pubmed:meshHeading | pubmed-meshheading:10669261... | lld:pubmed |
| pubmed-article:10669261 | pubmed:meshHeading | pubmed-meshheading:10669261... | lld:pubmed |
| pubmed-article:10669261 | pubmed:meshHeading | pubmed-meshheading:10669261... | lld:pubmed |
| pubmed-article:10669261 | pubmed:meshHeading | pubmed-meshheading:10669261... | lld:pubmed |
| pubmed-article:10669261 | pubmed:meshHeading | pubmed-meshheading:10669261... | lld:pubmed |
| pubmed-article:10669261 | pubmed:meshHeading | pubmed-meshheading:10669261... | lld:pubmed |
| pubmed-article:10669261 | pubmed:meshHeading | pubmed-meshheading:10669261... | lld:pubmed |
| pubmed-article:10669261 | pubmed:meshHeading | pubmed-meshheading:10669261... | lld:pubmed |
| pubmed-article:10669261 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10669261 | pubmed:articleTitle | Antiviral properties of a mangrove plant, Rhizophora apiculata Blume, against human immunodeficiency virus. | lld:pubmed |
| pubmed-article:10669261 | pubmed:affiliation | Department of Microbiology and Immunology, Kagoshima University Dental School, Japan. | lld:pubmed |
| pubmed-article:10669261 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10669261 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10669261 | lld:pubmed |
