| pubmed-article:10666384 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10666384 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10666384 | lifeskim:mentions | umls-concept:C1302401 | lld:lifeskim |
| pubmed-article:10666384 | lifeskim:mentions | umls-concept:C0387583 | lld:lifeskim |
| pubmed-article:10666384 | lifeskim:mentions | umls-concept:C0205422 | lld:lifeskim |
| pubmed-article:10666384 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:10666384 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10666384 | pubmed:dateCreated | 2000-3-9 | lld:pubmed |
| pubmed-article:10666384 | pubmed:abstractText | A putative target for the anti-colorectal cancer action of nonsteroidal anti-inflammatory drugs is the inducible isoform of cyclooxygenase (COX), COX-2. COX-2 is expressed within intestinal adenomas in murine polyposis models, but expression has been poorly characterized in human colorectal neoplasms. Therefore, we investigated the localization of the COX-2 protein in human sporadic colorectal adenomas. Immunohistochemistry for COX-2 and CD68 (a tissue macrophage marker) was performed on formalin-fixed, paraffin-embedded (n = 52) and frozen, acetone-fixed (n = 6) sections of human sporadic colorectal adenomas. Forty of 52 (77%) formalin-fixed adenomas expressed immunoreactive COX-2. COX-2 was localized to superficial interstitial macrophages in 39 cases (75%) and to deep interstitial macrophages in 9 cases (17%). COX-2 staining of dysplastic epithelial cells was observed in 15 cases (29%). A logistic regression analysis identified the adenoma site (P = 0.012) and histological type (P = 0.001) as independent predictors of superficial macrophage COX-2 expression. There was no relationship between the number of macrophages within an adenoma and macrophage COX-2 expression. These results indicate that COX-2 is expressed predominantly by interstitial macrophages within human sporadic colorectal adenomas. If COX-2 does indeed play a role in the early stages of colorectal carcinogenesis in man, these data suggest COX-2-mediated paracrine signaling between the macrophages and epithelial cells within adenomas. | lld:pubmed |
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| pubmed-article:10666384 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10666384 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:10666384 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10666384 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10666384 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:10666384 | pubmed:author | pubmed-author:GuillouP JPJ | lld:pubmed |
| pubmed-article:10666384 | pubmed:author | pubmed-author:MarkhamA FAF | lld:pubmed |
| pubmed-article:10666384 | pubmed:author | pubmed-author:HullM AMA | lld:pubmed |
| pubmed-article:10666384 | pubmed:author | pubmed-author:WindsorA CAC | lld:pubmed |
| pubmed-article:10666384 | pubmed:author | pubmed-author:ScottNN | lld:pubmed |
| pubmed-article:10666384 | pubmed:author | pubmed-author:ColettaP LPL | lld:pubmed |
| pubmed-article:10666384 | pubmed:author | pubmed-author:CartwrightE... | lld:pubmed |
| pubmed-article:10666384 | pubmed:author | pubmed-author:BoniferCC | lld:pubmed |
| pubmed-article:10666384 | pubmed:author | pubmed-author:HawcroftGG | lld:pubmed |
| pubmed-article:10666384 | pubmed:author | pubmed-author:TisburyAA | lld:pubmed |
| pubmed-article:10666384 | pubmed:author | pubmed-author:ChappleK SKS | lld:pubmed |
| pubmed-article:10666384 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10666384 | pubmed:volume | 156 | lld:pubmed |
| pubmed-article:10666384 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10666384 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10666384 | pubmed:pagination | 545-53 | lld:pubmed |
| pubmed-article:10666384 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10666384 | pubmed:meshHeading | pubmed-meshheading:10666384... | lld:pubmed |
| pubmed-article:10666384 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10666384 | pubmed:articleTitle | Localization of cyclooxygenase-2 in human sporadic colorectal adenomas. | lld:pubmed |
| pubmed-article:10666384 | pubmed:affiliation | Molecular Medicine Unit, Department of Histopathology, University of Leeds, St. James's University Hospital, Leeds, United Kingdom. | lld:pubmed |
| pubmed-article:10666384 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10666384 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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