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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-3-9
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pubmed:abstractText |
A putative target for the anti-colorectal cancer action of nonsteroidal anti-inflammatory drugs is the inducible isoform of cyclooxygenase (COX), COX-2. COX-2 is expressed within intestinal adenomas in murine polyposis models, but expression has been poorly characterized in human colorectal neoplasms. Therefore, we investigated the localization of the COX-2 protein in human sporadic colorectal adenomas. Immunohistochemistry for COX-2 and CD68 (a tissue macrophage marker) was performed on formalin-fixed, paraffin-embedded (n = 52) and frozen, acetone-fixed (n = 6) sections of human sporadic colorectal adenomas. Forty of 52 (77%) formalin-fixed adenomas expressed immunoreactive COX-2. COX-2 was localized to superficial interstitial macrophages in 39 cases (75%) and to deep interstitial macrophages in 9 cases (17%). COX-2 staining of dysplastic epithelial cells was observed in 15 cases (29%). A logistic regression analysis identified the adenoma site (P = 0.012) and histological type (P = 0.001) as independent predictors of superficial macrophage COX-2 expression. There was no relationship between the number of macrophages within an adenoma and macrophage COX-2 expression. These results indicate that COX-2 is expressed predominantly by interstitial macrophages within human sporadic colorectal adenomas. If COX-2 does indeed play a role in the early stages of colorectal carcinogenesis in man, these data suggest COX-2-mediated paracrine signaling between the macrophages and epithelial cells within adenomas.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666384-10188882,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10666384-9739782
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0002-9440
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pubmed:author |
pubmed-author:BoniferCC,
pubmed-author:CartwrightE JEJ,
pubmed-author:ChappleK SKS,
pubmed-author:ColettaP LPL,
pubmed-author:GuillouP JPJ,
pubmed-author:HawcroftGG,
pubmed-author:HullM AMA,
pubmed-author:MarkhamA FAF,
pubmed-author:ScottNN,
pubmed-author:TisburyAA,
pubmed-author:WindsorA CAC
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pubmed:issnType |
Print
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pubmed:volume |
156
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
545-53
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10666384-Adenoma,
pubmed-meshheading:10666384-Colorectal Neoplasms,
pubmed-meshheading:10666384-Cyclooxygenase 2,
pubmed-meshheading:10666384-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:10666384-Humans,
pubmed-meshheading:10666384-Immunohistochemistry,
pubmed-meshheading:10666384-Isoenzymes,
pubmed-meshheading:10666384-Membrane Proteins,
pubmed-meshheading:10666384-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:10666384-Tissue Distribution
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pubmed:year |
2000
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pubmed:articleTitle |
Localization of cyclooxygenase-2 in human sporadic colorectal adenomas.
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pubmed:affiliation |
Molecular Medicine Unit, Department of Histopathology, University of Leeds, St. James's University Hospital, Leeds, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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