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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2000-11-3
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pubmed:abstractText |
Data from naturally infected deer mice (Peromyscus maniculatus) were used to investigate vertical transmission of Sin Nombre virus (SNV) and SNV-specific antibody. The antibody prevalence in juvenile mice (14 g or less) was inversely proportional to the mass of the animal, with juvenile deer mice weighing less than 11 g most likely to be antibody positive (26.9%) and juvenile mice weighing between 13 and 14 g least likely to be antibody positive (12.9%). Although a significant sex bias in seropositivity was detected in adult deer mice, no significant sex bias in seropositivity was detected in juvenile animals. Ten juvenile deer mice were identified that had initially tested positive for SNV-specific immunoglobulin G (IgG) by enzyme-linked immunosorbent assay (ELISA) but had subsequently tested negative when recaptured as adults. SNV RNA was detected by reverse transcriptase PCR (RT-PCR) in the blood of ELISA-positive adult deer mice but not in the blood of ELISA-positive juveniles. One of the juvenile mice initially tested negative for SNV RNA but later tested positive when recaptured as an ELISA-positive adult. The RT-PCR results for that individual correlated with the disappearance and then reappearance of SNV-specific IgG, indicating that the presence of SNV RNA at later time points was due to infection with SNV via horizontal transmission. SNV-specific antibody present in both ELISA-positive juvenile and adult mice was capable of neutralizing SNV. Additionally, our data indicate that SNV is not transmitted vertically.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-10081677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-10081678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-10081680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-10081681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-10401910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-2179464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-2861296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-6786119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-7483255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-7811854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-7853545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-7872437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-7908999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-7984010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-8084007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-8109165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-8195603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-8235615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-8659118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-9129529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-9420200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-9498428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-9684629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-9749642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666274-9847363
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2426-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10666274-Age Factors,
pubmed-meshheading:10666274-Animals,
pubmed-meshheading:10666274-Antibodies, Viral,
pubmed-meshheading:10666274-California,
pubmed-meshheading:10666274-Cohort Studies,
pubmed-meshheading:10666274-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10666274-Female,
pubmed-meshheading:10666274-Hantavirus,
pubmed-meshheading:10666274-Hantavirus Infections,
pubmed-meshheading:10666274-Infectious Disease Transmission, Vertical,
pubmed-meshheading:10666274-Male,
pubmed-meshheading:10666274-Nevada,
pubmed-meshheading:10666274-Peromyscus,
pubmed-meshheading:10666274-Prevalence,
pubmed-meshheading:10666274-RNA, Viral,
pubmed-meshheading:10666274-Rodent Diseases,
pubmed-meshheading:10666274-Rodentia,
pubmed-meshheading:10666274-Seroepidemiologic Studies,
pubmed-meshheading:10666274-Sex Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Role of maternal antibody in natural infection of Peromyscus maniculatus with Sin Nombre virus.
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pubmed:affiliation |
Department of Microbiology, Desert Research Institute, University of Nevada, Reno, Reno, Nevada 89557, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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