| pubmed-article:10666191 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10666191 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:10666191 | lifeskim:mentions | umls-concept:C0023448 | lld:lifeskim |
| pubmed-article:10666191 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:10666191 | lifeskim:mentions | umls-concept:C2754998 | lld:lifeskim |
| pubmed-article:10666191 | lifeskim:mentions | umls-concept:C0020843 | lld:lifeskim |
| pubmed-article:10666191 | lifeskim:mentions | umls-concept:C1817697 | lld:lifeskim |
| pubmed-article:10666191 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10666191 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10666191 | pubmed:dateCreated | 2000-3-14 | lld:pubmed |
| pubmed-article:10666191 | pubmed:abstractText | Previously, we demonstrated that B-chronic lymphocytic leukemia (B-CLL) cells could be divided into 2 groups depending on the expression of CD38 by the malignant cells. The 2 groups differed in their signal-transducing capacities initiated by cross-linking of surface IgM; only in CD38-positive cells was an efficient signal delivered, invariably resulting in cell apoptosis. In this study, we investigated the effect of surface IgD cross-linking in 10 patients with CD38-positive B-CLL. Exposure of the malignant cells to goat antihuman delta-chain antibodies (Gadelta-ab) caused [Ca(++)]i mobilization and tyrosine kinase phosphorylation in a manner not different from that observed after goat antihuman mu-chain antibody (Gamu-ab) treatment in vitro. However, Gadelta-ab-treated cells failed to undergo apoptosis and instead displayed prolonged survival in culture and differentiated into plasma cells when rIL2 was concomitantly present. Cross-linking of surface IgD failed to induce proliferation of the malignant cells in vitro. Moreover, treatment with Gadelta-ab did not prevent apoptosis of B-CLL cells induced by Gamu-ab. Collectively, these experiments demonstrated that IgM and IgD expressed by the same cell may deliver opposite signals under particular circumstances and provide some clues for the understanding of the pathophysiology of B-CLL. (Blood. 2000;95:1199-1206) | lld:pubmed |
| pubmed-article:10666191 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666191 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10666191 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666191 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10666191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10666191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10666191 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10666191 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10666191 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:10666191 | pubmed:author | pubmed-author:RossiEE | lld:pubmed |
| pubmed-article:10666191 | pubmed:author | pubmed-author:MalavasiFF | lld:pubmed |
| pubmed-article:10666191 | pubmed:author | pubmed-author:FerrariniMM | lld:pubmed |
| pubmed-article:10666191 | pubmed:author | pubmed-author:DongEE | lld:pubmed |
| pubmed-article:10666191 | pubmed:author | pubmed-author:CosulichM EME | lld:pubmed |
| pubmed-article:10666191 | pubmed:author | pubmed-author:ZupoSS | lld:pubmed |
| pubmed-article:10666191 | pubmed:author | pubmed-author:MassaraRR | lld:pubmed |
| pubmed-article:10666191 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10666191 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10666191 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:10666191 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10666191 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10666191 | pubmed:pagination | 1199-206 | lld:pubmed |
| pubmed-article:10666191 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:10666191 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10666191 | pubmed:articleTitle | Apoptosis or plasma cell differentiation of CD38-positive B-chronic lymphocytic leukemia cells induced by cross-linking of surface IgM or IgD. | lld:pubmed |
| pubmed-article:10666191 | pubmed:affiliation | Servizio di Immunologia Clinica, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy. szupo@hp380.ist.unige.it | lld:pubmed |
| pubmed-article:10666191 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10666191 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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