Linked Life Data

10665416

Source:http://linkedlifedata.com/resource/pubmed/id/10665416

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-2-17
pubmed:abstractText
In order to evaluate the risk to the environment from long term exposure of any discharged substance, toxicity thresholds are estimated, and particularly the Predicted No Effect Concentration (PNEC). This concentration can be estimated by the classic assessment factor approach or by statistical methods. These are more scientifically sound but they require several (at least 5-6) chronic ecotoxicity data, implying greater cost and time. New extrapolation methods derived from the statistical concept but requiring less data have been studied. Results show that methods based on chronic data are more reliable than methods based on acute data but the improvement is quite small. Considering the costs of chronic tests compared to acute tests, approaches based on acute data are an attractive alternative. A simple regression on the mean of the acute data gives the best results.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0045-6535
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
267-73
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Evaluation of PNEC values: extrapolation from Microtox, algae, daphnid, and fish data to HC5.
pubmed:affiliation
Rhône Poulenc Industrialisation, Décines, France.
pubmed:publicationType
Journal Article