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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1976-10-20
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pubmed:abstractText |
Forty-five children with acute nonlymphoblastic leukemia in relapse received a total of 56 courses of L-asparaginase combined with vincristine and prednisone. The complete remission rate of 40% (12 of 30 trials) in patients resistant to vincristine and prednisone was almost identical to that in children still sensitive to vincristine and prednisone (42%, 11 of 26 trials). The complete remission rate of 38% (14 of 37 exposures) in those children who had not received L-asparaginase previously compared favorably with the complete remission rate in those children who had received prior L-asparaginase (47%, 9 of 19 exposures). Forty-seven of the 56 induction trials were in children with 1 or more remissions and 14 of these were in children with 3 or more prior remissions. Toxicity was minimal.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0098-1532
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
191-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1066523-Acute Disease,
pubmed-meshheading:1066523-Asparaginase,
pubmed-meshheading:1066523-Child,
pubmed-meshheading:1066523-Drug Therapy, Combination,
pubmed-meshheading:1066523-Female,
pubmed-meshheading:1066523-Hepatomegaly,
pubmed-meshheading:1066523-Humans,
pubmed-meshheading:1066523-Leukemia,
pubmed-meshheading:1066523-Leukemia, Erythroblastic, Acute,
pubmed-meshheading:1066523-Leukemia, Myeloid,
pubmed-meshheading:1066523-Leukocyte Count,
pubmed-meshheading:1066523-Male,
pubmed-meshheading:1066523-Prednisone,
pubmed-meshheading:1066523-Remission, Spontaneous,
pubmed-meshheading:1066523-Splenomegaly,
pubmed-meshheading:1066523-Vincristine
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pubmed:year |
1976
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pubmed:articleTitle |
Remission induction with L-asparaginase, vincristine, and prednisone in children with acute nonlymphoblastic leukemia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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