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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-3-13
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pubmed:abstractText |
Ring-opening metathesis polymerization (ROMP) is a powerful synthetic method for generating unique materials. The functional group tolerance of ruthenium ROMP initiators allows the synthesis of a wide range of biologically active polymers. We generated multivalent ligands that inhibit cell surface L-selectin, a protein that mediates lymphocyte homing and leukocyte recruitment in inflammation. We hypothesized that these ligands function through specific, multivalent binding to L-selection. To examine this and to develop a general method for synthesizing multivalent materials with end-labels, we investigated functionalized enol ethers as capping agents in ruthenium-initiated ROMP.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1074-5521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9-16
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10662681-Carbohydrates,
pubmed-meshheading:10662681-Fluoresceins,
pubmed-meshheading:10662681-Fluorescent Dyes,
pubmed-meshheading:10662681-HL-60 Cells,
pubmed-meshheading:10662681-Humans,
pubmed-meshheading:10662681-Indicators and Reagents,
pubmed-meshheading:10662681-Jurkat Cells,
pubmed-meshheading:10662681-L-Selectin,
pubmed-meshheading:10662681-Ligands,
pubmed-meshheading:10662681-Microscopy, Fluorescence,
pubmed-meshheading:10662681-Protein Binding,
pubmed-meshheading:10662681-Receptor Aggregation,
pubmed-meshheading:10662681-Receptors, Cell Surface,
pubmed-meshheading:10662681-Ruthenium
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pubmed:year |
2000
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pubmed:articleTitle |
Synthesis of end-labeled multivalent ligands for exploring cell-surface-receptor-ligand interactions.
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pubmed:affiliation |
Departments of Chemistry and Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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