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pubmed-article:10660762pubmed:abstractTextThe 21-aminosteroid (U-74389G) is a nonglucocorticoid steroid that was synthesized to inhibit lipid peroxidation without the glucocorticoid activity. We recently demonstrated that the 21-aminosteroid administered to endotoxin shock mice reduces liver injury and improves the survival rate of mice through inhibition of nuclear factor-kappa B activation in the liver. The study was undertaken to determine whether the 21-aminosteroid could suppress pro-inflammatory gene up-regulation through inhibition of nuclear factor-kappa B activation in Kupffer cells.lld:pubmed
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pubmed-article:10660762pubmed:articleTitleEffect of the 21-aminosteroid on nuclear factor-kappa B activation of Kupffer cells in endotoxin shock.lld:pubmed
pubmed-article:10660762pubmed:affiliationSecond Department of Surgery, Hiroshima University School of Medicine, Japan.lld:pubmed
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