|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2000-2-17
|
|
pubmed:abstractText |
The 21-aminosteroid (U-74389G) is a nonglucocorticoid steroid that was synthesized to inhibit lipid peroxidation without the glucocorticoid activity. We recently demonstrated that the 21-aminosteroid administered to endotoxin shock mice reduces liver injury and improves the survival rate of mice through inhibition of nuclear factor-kappa B activation in the liver. The study was undertaken to determine whether the 21-aminosteroid could suppress pro-inflammatory gene up-regulation through inhibition of nuclear factor-kappa B activation in Kupffer cells.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0039-6060
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
127
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
79-86
|
|
pubmed:dateRevised |
2005-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:10660762-Animals,
pubmed-meshheading:10660762-Antioxidants,
pubmed-meshheading:10660762-Cells, Cultured,
pubmed-meshheading:10660762-Dose-Response Relationship, Drug,
pubmed-meshheading:10660762-I-kappa B Proteins,
pubmed-meshheading:10660762-Interleukin-6,
pubmed-meshheading:10660762-Kupffer Cells,
pubmed-meshheading:10660762-Lipopolysaccharides,
pubmed-meshheading:10660762-Male,
pubmed-meshheading:10660762-NF-kappa B,
pubmed-meshheading:10660762-Pregnatrienes,
pubmed-meshheading:10660762-RNA, Messenger,
pubmed-meshheading:10660762-Rats,
pubmed-meshheading:10660762-Rats, Wistar,
pubmed-meshheading:10660762-Shock, Septic,
pubmed-meshheading:10660762-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Effect of the 21-aminosteroid on nuclear factor-kappa B activation of Kupffer cells in endotoxin shock.
|
|
pubmed:affiliation |
Second Department of Surgery, Hiroshima University School of Medicine, Japan.
|
|
pubmed:publicationType |
Journal Article
|
