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| pubmed-article:10660577 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:10660577 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:10660577 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:10660577 | lifeskim:mentions | umls-concept:C0041491 | lld:lifeskim |
| pubmed-article:10660577 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:10660577 | lifeskim:mentions | umls-concept:C0282151 | lld:lifeskim |
| pubmed-article:10660577 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10660577 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:10660577 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10660577 | pubmed:dateCreated | 2000-3-16 | lld:pubmed |
| pubmed-article:10660577 | pubmed:abstractText | Treatment of dopaminergic rat PC12 cells with human immunodeficiency virus, type 1 (HIV-1) Tat protein or tat cDNA inhibited the expression of tyrosine hydroxylase (TH), the rate-limiting enzyme for the dopamine biosynthetic pathway, as well as the production and release of dopamine into the culture medium. Moreover, the Tat addition to PC12 cells up-regulated the expression of the inducible cAMP early repressor (ICER), a specific member of the cAMP-responsive element modulator transcription factor family, in a cAMP-dependent manner. In turn, ICER overexpression abrogated the transcription activity of the TH promoter in PC12 cells, strongly suggesting ICER involvement in Tat-mediated inhibition of TH gene expression. In vivo injection of synthetic HIV-1 Tat protein into the striatum of healthy rats induced a subclinical Parkinson's-like disease that became manifested only when the animals were treated with amphetamine. As early as one week postinjection, the histochemical examination of the rat substantia nigra showed a reduced staining of neurons expressing TH followed by a loss of TH(+) neurons at later time points. As Tat protein can be locally released into the central nervous system by HIV-1-infected microglial cells, our findings may contribute to the explanation of the pathogenesis of the motorial abnormalities often reported in HIV-1 seropositive individuals. | lld:pubmed |
| pubmed-article:10660577 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10660577 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10660577 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10660577 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10660577 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10660577 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10660577 | pubmed:author | pubmed-author:CapitaniSS | lld:pubmed |
| pubmed-article:10660577 | pubmed:author | pubmed-author:MazzoniMM | lld:pubmed |
| pubmed-article:10660577 | pubmed:author | pubmed-author:ZauliGG | lld:pubmed |
| pubmed-article:10660577 | pubmed:author | pubmed-author:VitaleMM | lld:pubmed |
| pubmed-article:10660577 | pubmed:author | pubmed-author:GibelliniDD | lld:pubmed |
| pubmed-article:10660577 | pubmed:author | pubmed-author:SecchieroPP | lld:pubmed |
| pubmed-article:10660577 | pubmed:author | pubmed-author:MirandolaPP | lld:pubmed |
| pubmed-article:10660577 | pubmed:author | pubmed-author:MilaniDD | lld:pubmed |
| pubmed-article:10660577 | pubmed:author | pubmed-author:DowdD RDR | lld:pubmed |
| pubmed-article:10660577 | pubmed:author | pubmed-author:RodellaLL | lld:pubmed |
| pubmed-article:10660577 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10660577 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:10660577 | pubmed:volume | 275 | lld:pubmed |
| pubmed-article:10660577 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10660577 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10660577 | pubmed:pagination | 4159-65 | lld:pubmed |
| pubmed-article:10660577 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:10660577 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10660577 | pubmed:articleTitle | HIV-1 Tat-mediated inhibition of the tyrosine hydroxylase gene expression in dopaminergic neuronal cells. | lld:pubmed |
| pubmed-article:10660577 | pubmed:affiliation | Department of Morphology and Embryology, Anatomy Section, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy. zlg@dns.unife.it | lld:pubmed |
| pubmed-article:10660577 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10660577 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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