Linked Life Data

10659318

Source:http://linkedlifedata.com/resource/pubmed/id/10659318

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2000-3-2
pubmed:abstractText
Six young (mean + s.e., 5.3 +/- 0.8 years, 445 +/- 13 kg bwt) and 6 old (22.0 +/- 0.4 years, 473 +/- 18 kg bwt) Standardbred and Thoroughbred mares were used to test the hypothesis that age would alter the endocrine response to exercise. All of the mares were unconditioned but accustomed to the laboratory, to standing quietly and running on a treadmill, and to the standardised incremental exercise test (SET) used in the experiment. Two weeks prior to the experiment, each horse underwent a SET to determine maximal oxygen uptake (VO2max) and the speeds to be used in the actual experiment. A second graded exercise test (GXT) was performed without instrumentation for the measurement of plasma renin activity (PRA) and the plasma concentrations of atrial natriuretic peptide (ANP), arginine vasopressin (AVP), aldosterone (ALDO), and endothelin-1 (ET-1). Blood samples (30 ml) were collected at rest and at the end of each one minute step of the exercise test. Plasma concentrations of hormones were measured using radioimmunoassay kits. There were no differences (P > 0.05) between old vs. young mares for resting PRA (2.2 +/- 0.3 vs. 1.5 +/- 0.3 ng/ml/h), or the plasma concentrations of ANP (10.0 +/- 0.9 vs. 10.7 +/- 0.6 pg/ml); AVP (0.7 + 0.7 vs. 1.4 +/- 0.4 pg/ml); ALDO (39.2 +/- 10.3 vs. 22.7 +/- 4.6 pg/ml); or ET-1 (0.23 +/- 0.04 vs. 0.18 +/- 0.03 pg/ml). Exercise significantly increased PRA and the concentrations of ANP, AVP, and ALDO in both groups of horses; however, ET-1 was not altered (P > 0.05) by exercise in either group. There were differences (P < 0.05) between means obtained from the old and young groups for PRA (5.4 +/- 0.6 vs. 3.9 +/- 0.8 ng/ml/h and the concentrations of ANP (14.5 +/- 2.3 vs. 26.5 +/- 9.0 pg/ml), AVP (13.6 +/- 0.3 vs. 26.1 +/- 13.9 pg/ml, and ALDO (76.8 +/- 22.0 vs. 41.5 +/- 4.9 pg/ml) measured in samples obtained at the speed eliciting VO2max. These data suggest that older horses have an age-altered endocrine response to exercise.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:author
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
561-6
pubmed:dateRevised
2007-5-18
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Endocrine response to exercise in young and old horses.
pubmed:affiliation
Department of Animal Science, Cook College, Rutgers-State University of New Jersey, New Brunswick 08901, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't