Linked Life Data

10659233

Source:http://linkedlifedata.com/resource/pubmed/id/10659233

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2000-3-2
pubmed:abstractText
In order to evaluate the pulmonary gas exchange during exercise in Standardbred trotters with red cell hypervolaemia (RCHV), 12 horses with RCHV were compared with 9 normovolaemic (NV) horses. VO2 and VCO2 were determined with an open bias flow system. Cardiovascular and haemodynamic data were recorded during exercise at 4 different speeds on a treadmill. Pulmonary gas exchange was assessed by conventional blood gas variables (arterial and mixed venous blood gas tensions), and the ventilation-perfusion distribution VA/Q was estimated by the multiple inert gas elimination technique. VA and AaDO2 were calculated. Dispersions of perfusion and ventilation distribution (SDQ, SDV) were determined. HR, RR, Qt, VO2, VA, log SDV, C(a-åv)O2 and lactate did not differ between groups. The degree of hypoxaemia was more pronounced in the RCHV than in the NV (PaO2 = 54 and 59 mmHg; AaDO2 = 41 and 34 mmHg in RCHV and NV, respectively, at highest workload). Further, pH was lower in the RCHV and PaCO2 and VCO2 was significantly higher in the RCHV during the course of exercise (pH = 7.24 and 7.29; PaCO2 = 56 and 51 mmHg; VCO2 = 156 and 135 ml/kg x min in RCHV and NV, respectively, at highest workload). The PaO2 predicted from the VA/Q distribution was higher than actually measured in blood during heavy exercise which may suggest a certain diffusion limitation over the alveolar-capillary membranes in both groups but there was no difference between the 2 groups. The more pronounced hypoxaemia observed in RCHV trotters was mainly caused by increased VA/Q mismatch expressed as a significantly increased log SDQ (0.78 and 0.45 in RCHV and NV, respectively, at highest workload).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:author
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
107-13
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Ventilation-perfusion relationships during exercise in standardbred trotters with red cell hypervolaemia.
pubmed:affiliation
Department of Large Animal Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't