Linked Life Data

10658954

Source:http://linkedlifedata.com/resource/pubmed/id/10658954

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-2-25
pubmed:abstractText
The mechanisms by which the brain times events and stores them in memory for later use is increasingly of interest to neuroscientists. There are a variety of neurological disorders in which skilled behaviors are not coordinated and appear less than fluent, which may suggest a disorder in temporal processing. In this review, two influential models are described which suggest timing deficits may be due to impairments in a timekeeping mechanism or various nontemporal processes such as motor implementation, memory, and attention. We then review focal lesion, pharmacological, and functional imaging approaches to understanding the neural underpinnings of temporal processing. Converging findings from these approaches provide support for the role of the basal ganglia in timekeeping operations. Likewise, focal lesion and some functional imaging studies are compatible with a timekeeping role of the cerebellum, though specific regions within the cerebellum that control timing operations have not been identified. In contrast, the results from recent focal lesion research suggests the right middle-frontal and inferior-parietal cortices comprise a pathway that supports attention and working memory operations, which are crucial for timing. Functional imaging data provide some converging evidence for this proposal. Functional imaging work also indicates that a right superior-temporal inferior-frontal pathway sometimes aids timing through subvocal nonlinguistic rehearsal processes. These distributed pathways maintain timekeeping operations in working memory and store representations of temporal events, which is crucial for skilled performance.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0334-1763
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-116
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Neural underpinnings of temporal processing: a review of focal lesion, pharmacological, and functional imaging research.
pubmed:affiliation
Department of Veterans Affairs and the Department of Neurology, University of New Mexico, Albuquerque 87108, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review