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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1976-10-2
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pubmed:abstractText |
Purine nucleoside analogs modified by replacement of the nitrogen atom at the 3 position by a CH group give a characteristic circular dichroism curve that is not substantially modified by chemical substitution at the 8 position. Since it is rather well established that 8-substituted purine nucleosides are predominantly in the syn conformation in aqueous solution, it follows that the 3-deazapurine nucleosides, whether substituted at position 8 or not, also favor the syn conformation. These data are in sharp contrast to the circular dichroism data obtained on 8-halogenated and 8-alkylated derivatives of adenosine and guanosine, which give circular dichroism profiles substantially different from those obtained on the parent compounds. Certain purine-nucleoside-utilizing enzymes fail to interact effectively with either the unsubstituted 3-deaza analogs or the 8-substituted derivatives of adenosine and guanosine. The hypothesis recently given that the inactivity of the 8-substituted derivatives springs from their syn-conformational preference is tentatively accepted to explain the inactivity of the 3-deaza analogs.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-1133342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-1169240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-1195043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-14003159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-4202101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-4334404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-4436263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-4676271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-4733812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-4736248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-4844632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-4850243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-5038707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-5059890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-5168598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-5253660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-5461216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-5550248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-5648867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-5671276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-5696273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-5797997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-5940959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1065890-5958937
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2384-7
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pubmed:dateRevised |
2010-9-3
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pubmed:meshHeading |
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pubmed:year |
1976
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pubmed:articleTitle |
Comparative study by circular dichroism of the conformation of deazapurine nucleosides and that of common purine nucleosides.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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