Source:http://linkedlifedata.com/resource/pubmed/id/10658672
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2000-2-15
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pubmed:abstractText |
Polyploidy, the state of having greater than the diploid content of DNA, has been recognized in a variety cells. Among these cell types, the megakaryocytes are classified as obligate polyploid cells, developing a polyploid DNA content regularly during the normal life cycle of the organism, while other cells may become polyploid only in response to certain stimuli. The objective of this review is to briefly describe the different cell cycle alterations that may lead to high ploidy, while focusing on the megakaryocyte and the importance of high ploidy to platelet level and function.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0301-472X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3-16
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10658672-Animals,
pubmed-meshheading:10658672-Blood Platelets,
pubmed-meshheading:10658672-Cardiovascular Diseases,
pubmed-meshheading:10658672-Cell Cycle,
pubmed-meshheading:10658672-DNA,
pubmed-meshheading:10658672-Diploidy,
pubmed-meshheading:10658672-Humans,
pubmed-meshheading:10658672-Leukemia,
pubmed-meshheading:10658672-Megakaryocytes,
pubmed-meshheading:10658672-Mitosis,
pubmed-meshheading:10658672-Myeloproliferative Disorders,
pubmed-meshheading:10658672-Polyploidy
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pubmed:year |
2000
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pubmed:articleTitle |
Polyploidy: occurrence in nature, mechanisms, and significance for the megakaryocyte-platelet system.
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pubmed:affiliation |
Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Mass. 02118, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
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