Linked Life Data

10658193

Source:http://linkedlifedata.com/resource/pubmed/id/10658193

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-2-25
pubmed:abstractText
Acute doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) elicited degenerative and apparently compensatory changes in the nigrostriatum of injected animals within 1 day of treatment. In the substantia nigra pars compacta (SNc), low-dose (20 mg/kg) administration elicited early degeneration of mitochondria in the absence of other effects. In the striatum, a low MPTP dose resulted in myelin unwinding, demyelination, cytoplasmic shrinkage, and disturbance of synaptic communication, as evinced by a profound reduction in synaptic vesicle production. High-dose (40 mg/kg) administration generated more drastic axonal degeneration leading to cell elimination in the striatum. At neither dose was mitochondrial disturbance evident in the striatum. Evidence is presented that darkened synaptic boutons, visible at this level of MPTP administration, were part of healthy enlarged axons with an elevated number of synaptic contacts. These spared neuronal processes, therefore, were hypothesized to compensate for the MPTP-induced death of dopaminergic neurons by adaptive structural modifications that would serve to enhance their functional capability.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0360-4012
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
126-35
pubmed:dateRevised
2007-3-21
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Acute ultrastructural effects of MPTP on the nigrostriatal pathway of the C57BL/6 adult mouse: evidence of compensatory plasticity in nigrostriatal neurons.
pubmed:affiliation
Department of Biological Sciences, San Jose State University, California 95192, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't